Metformin and FTY720 Synergistically Induce Apoptosis in Multiple Myeloma Cells

Metformin and FTY720 Synergistically Induce Apoptosis in Multiple Myeloma Cells

Background/Aims: Patients with multiple myeloma (MM) invariably relapse with chemotherapy-resistant disease, underscoring the need for new therapeutic options that bypass these resistance mechanisms. Metformin is a widely prescribed antidiabetic drug with direct antitumor activity against various tu...

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Hlavní autoři: Yi Zhao, Enfan Zhang, Ning Lv, Liang Ma, Shunnan Yao, Meidi Yan, Fumin Zi, Gang Deng, Xinling Liu, Jingsong He, Wenjun Wu, Zhen Cai, Rui Yu
Médium: Článek
Jazyk:English
Vydáno: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Edice:Cellular Physiology and Biochemistry
Témata:
Multiple myeloma
Metformin
FTY720
Apoptosis
ER stress
Mitochondrial membrane potential
ROS
On-line přístup:https://www.karger.com/Article/FullText/491908

Internet

https://www.karger.com/Article/FullText/491908

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