Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes
The cumulative incidence of diabetic nephropathy in Type 1 diabetes mellitus is in the order of 25—30%. The recognition that elevated blood pressure (BP) is a major factor in the progression of these patients to end-stage renal failure has led to the widespread use of antihypertensive therapy in ord...
| Main Author: | |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2002-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.3317/jraas.2002.044 |
| _version_ | 1797288692465795072 |
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| author | Løgstrup Poulsen |
| author_facet | Løgstrup Poulsen |
| author_sort | Løgstrup Poulsen |
| collection | DOAJ |
| description | The cumulative incidence of diabetic nephropathy in Type 1 diabetes mellitus is in the order of 25—30%. The recognition that elevated blood pressure (BP) is a major factor in the progression of these patients to end-stage renal failure has led to the widespread use of antihypertensive therapy in order to preserve glomerular filtration rate and ultimately to reduce mortality. The routine measurement of microalbuminuria allows early identification of the subgroup of patients at increased risk of developing clinical nephropathy. Microalbuminuric Type 1 diabetic patients show a number of characteristic pathological abnormalities. In addition to elevated BP and abnormal circadian rhythm, there are also associated abnormalities of vagal function, lipid profile and endothelial function, as well as an increased prevalence of retinopathy. The first section of this two-part review focusses on the early changes associated with renal involvement in Type 1 diabetes. It addresses the associations between urinary albumin excretion, glycaemic control, smoking, BP, circadian BP variation, QT interval abnormalities and autonomic function in three groups of patients; those with normoalbuminuria, those progressing towards microalbuminuria and those with established low-grade microalbuminuria. |
| first_indexed | 2024-03-07T18:53:11Z |
| format | Article |
| id | doaj.art-3b2b4406fdaf42d7b4fa187226b490db |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T18:53:11Z |
| publishDate | 2002-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-3b2b4406fdaf42d7b4fa187226b490db2024-03-02T00:52:34ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032002-12-01310.3317/jraas.2002.044Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetesLøgstrup PoulsenThe cumulative incidence of diabetic nephropathy in Type 1 diabetes mellitus is in the order of 25—30%. The recognition that elevated blood pressure (BP) is a major factor in the progression of these patients to end-stage renal failure has led to the widespread use of antihypertensive therapy in order to preserve glomerular filtration rate and ultimately to reduce mortality. The routine measurement of microalbuminuria allows early identification of the subgroup of patients at increased risk of developing clinical nephropathy. Microalbuminuric Type 1 diabetic patients show a number of characteristic pathological abnormalities. In addition to elevated BP and abnormal circadian rhythm, there are also associated abnormalities of vagal function, lipid profile and endothelial function, as well as an increased prevalence of retinopathy. The first section of this two-part review focusses on the early changes associated with renal involvement in Type 1 diabetes. It addresses the associations between urinary albumin excretion, glycaemic control, smoking, BP, circadian BP variation, QT interval abnormalities and autonomic function in three groups of patients; those with normoalbuminuria, those progressing towards microalbuminuria and those with established low-grade microalbuminuria.https://doi.org/10.3317/jraas.2002.044 |
| spellingShingle | Løgstrup Poulsen Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes Journal of the Renin-Angiotensin-Aldosterone System |
| title | Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes |
| title_full | Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes |
| title_fullStr | Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes |
| title_full_unstemmed | Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes |
| title_short | Blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in Type 1 diabetes |
| title_sort | blood pressure and cardiac autonomic function in relation to risk factors and treatment perspectives in type 1 diabetes |
| url | https://doi.org/10.3317/jraas.2002.044 |
| work_keys_str_mv | AT løgstruppoulsen bloodpressureandcardiacautonomicfunctioninrelationtoriskfactorsandtreatmentperspectivesintype1diabetes |