Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps

We demonstrate a new synthetic strategy to cyclophanes containing thiophene and indole moieties via Grignard addition, Fischer indolization and ring-closing metathesis as key steps.

Bibliographic Details
Main Authors: Sambasivarao Kotha, Ajay Kumar Chinnam, Mukesh E. Shirbhate
Format: Article
Language:English
Published: Beilstein-Institut 2015-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.11.165
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author Sambasivarao Kotha
Ajay Kumar Chinnam
Mukesh E. Shirbhate
author_facet Sambasivarao Kotha
Ajay Kumar Chinnam
Mukesh E. Shirbhate
author_sort Sambasivarao Kotha
collection DOAJ
description We demonstrate a new synthetic strategy to cyclophanes containing thiophene and indole moieties via Grignard addition, Fischer indolization and ring-closing metathesis as key steps.
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spelling doaj.art-3b2bda6a99fe4bbfb1eb62fcb08bf37c2022-12-21T22:21:49ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-08-011111514151910.3762/bjoc.11.1651860-5397-11-165Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key stepsSambasivarao Kotha0Ajay Kumar Chinnam1Mukesh E. Shirbhate2Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400 076, India, Fax: 022-2572 7152Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400 076, India, Fax: 022-2572 7152Department of Chemistry, Indian Institute of Technology-Bombay, Powai, Mumbai-400 076, India, Fax: 022-2572 7152We demonstrate a new synthetic strategy to cyclophanes containing thiophene and indole moieties via Grignard addition, Fischer indolization and ring-closing metathesis as key steps.https://doi.org/10.3762/bjoc.11.165cyclophaneGrignard reactionFischer indolizationring-closing metathesis
spellingShingle Sambasivarao Kotha
Ajay Kumar Chinnam
Mukesh E. Shirbhate
Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps
Beilstein Journal of Organic Chemistry
cyclophane
Grignard reaction
Fischer indolization
ring-closing metathesis
title Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps
title_full Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps
title_fullStr Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps
title_full_unstemmed Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps
title_short Design and synthesis of hybrid cyclophanes containing thiophene and indole units via Grignard reaction, Fischer indolization and ring-closing metathesis as key steps
title_sort design and synthesis of hybrid cyclophanes containing thiophene and indole units via grignard reaction fischer indolization and ring closing metathesis as key steps
topic cyclophane
Grignard reaction
Fischer indolization
ring-closing metathesis
url https://doi.org/10.3762/bjoc.11.165
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