Double-Stranded RNA Enhances Matrix Metalloproteinase-1 and -13 Expressions through TLR3-Dependent Activation of Transglutaminase 2 in Dermal Fibroblasts

Double-Stranded RNA Enhances Matrix Metalloproteinase-1 and -13 Expressions through TLR3-Dependent Activation of Transglutaminase 2 in Dermal Fibroblasts

UV-irradiation induces the secretion of double-stranded RNA (dsRNA) derived from damaged noncoding RNAs in keratinocytes, which enhance the expression of matrix metalloproteinases (MMP) in non-irradiated dermal fibroblasts, leading to dysregulation of extracellular matrix homeostasis. However, the s...

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Bibliographic Details
Main Authors:	Ah-Young Hong, Seok-Jin Lee, Ki Baek Lee, Ji-Woong Shin, Eui Man Jeong, In-Gyu Kim
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	International Journal of Molecular Sciences
Subjects:	transglutaminase 2 double-stranded RNA (dsRNA) matrix metalloproteinases (MMP) dermal fibroblasts poly(I:C) ROS
Online Access:	https://www.mdpi.com/1422-0067/23/5/2709

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