Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice

Blockage of transient receptor potential vanilloid 4 inhibits brain edema in middle cerebral artery occlusion mice

Brain edema is an important pathological process during stroke. Activation of transient receptor potential vanilloid 4 (TRPV4) causes an up-regulation of matrix metalloproteinases (MMPs) in lung tissue. MMP can digest the endothelial basal lamina to destroy blood brain barrier, leading to vasogenic...

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Bibliographic Details
Main Authors: Pinghui eJie, Yujing eTian, Zhiwen eHong, Lin eLi, Libin eZhou, Lei eChen, Ling eChen
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Brain Edema
cerebral ischemia
matrix metalloproteinase
Tight junction protein
Transient receptor potential vanilloid 4
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00141/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00141/full

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