Abnormal functional lymphoid tolerance and enhanced myeloid exocytosis are characteristics of resting and stimulated PBMCs in cystic fibrosis patients

Abnormal functional lymphoid tolerance and enhanced myeloid exocytosis are characteristics of resting and stimulated PBMCs in cystic fibrosis patients

IntroductionCystic Fibrosis (CF) is the commonest genetically inherited disease (1 in 4,500 newborns) and 70% of people with CF (pwCF) harbour the F508Del mutation, resulting in misfolding and incorrect addressing of the channel CFTR to the epithelial membrane and subsequent dysregulation of fluid h...

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Bibliographic Details
Main Authors: Clémence Gaudin, Reem Ghinnagow, Flora Lemaire, Bérengère Villeret, Isabelle Sermet-Gaudelus, Jean-Michel Sallenave
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Immunology
Subjects:
cystic fibrosis
PBMCs
Pseudomonas aeruginosa
tolerance
proteases
lymphocyte
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1360716/full

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