Multiple myeloma following bone metastasis of renal cell carcinoma: a case report
BackgroundThe clinical manifestations of multiple myeloma (MM) and bone metastatic tumor are both systemic bone pain, which is difficult to distinguish from imaging manifestations, leading to misdiagnosis and missed diagnosis.Case summaryWe reported a man with a unique case whose tumors were MM with...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1206368/full |
| _version_ | 1797427145188835328 |
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| author | Hong Yu Shengnan Zhang Xiaohui Feng Feng Gao |
| author_facet | Hong Yu Shengnan Zhang Xiaohui Feng Feng Gao |
| author_sort | Hong Yu |
| collection | DOAJ |
| description | BackgroundThe clinical manifestations of multiple myeloma (MM) and bone metastatic tumor are both systemic bone pain, which is difficult to distinguish from imaging manifestations, leading to misdiagnosis and missed diagnosis.Case summaryWe reported a man with a unique case whose tumors were MM with bone metastatic tumor of clear cell renal cell carcinoma (CCRCC). Computed tomography (CT) showed multifocal osteolytic bone destruction, while magnetic resonance imaging (MRI) showed multifocal bone marrow infiltration with soft tissue mass. Pathology and immunohistochemistry established the diagnosis of the coexistence of myeloma with bone metastatic tumor of CCRCC in the spine. Immunotherapy and systemic chemotherapy were adopted in the clinic, and vertebral decompression was performed after anemia was corrected. This case with MM and bone metastatic tumor of CCRCC received radiotherapy and immunotherapy and acquired satisfying outcome after 1 year of follow-up.ConclusionIt is difficult to differentiate MM and bone metastatic tumor on imaging, especially when there are bone lesions at the same time, which is an easily missed diagnosis and needs to be comprehensively evaluated in combination with functional procedures, clinical laboratory tests, and histopathology. |
| first_indexed | 2024-03-09T08:40:42Z |
| format | Article |
| id | doaj.art-3b34cc7db9914c428f06277e35d29dd5 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-09T08:40:42Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3b34cc7db9914c428f06277e35d29dd52023-12-02T16:59:03ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-12-011410.3389/fendo.2023.12063681206368Multiple myeloma following bone metastasis of renal cell carcinoma: a case reportHong Yu0Shengnan Zhang1Xiaohui Feng2Feng Gao3Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathology, The Third Hospital of Hebei Medical University, Shijiazhuang, ChinaBackgroundThe clinical manifestations of multiple myeloma (MM) and bone metastatic tumor are both systemic bone pain, which is difficult to distinguish from imaging manifestations, leading to misdiagnosis and missed diagnosis.Case summaryWe reported a man with a unique case whose tumors were MM with bone metastatic tumor of clear cell renal cell carcinoma (CCRCC). Computed tomography (CT) showed multifocal osteolytic bone destruction, while magnetic resonance imaging (MRI) showed multifocal bone marrow infiltration with soft tissue mass. Pathology and immunohistochemistry established the diagnosis of the coexistence of myeloma with bone metastatic tumor of CCRCC in the spine. Immunotherapy and systemic chemotherapy were adopted in the clinic, and vertebral decompression was performed after anemia was corrected. This case with MM and bone metastatic tumor of CCRCC received radiotherapy and immunotherapy and acquired satisfying outcome after 1 year of follow-up.ConclusionIt is difficult to differentiate MM and bone metastatic tumor on imaging, especially when there are bone lesions at the same time, which is an easily missed diagnosis and needs to be comprehensively evaluated in combination with functional procedures, clinical laboratory tests, and histopathology.https://www.frontiersin.org/articles/10.3389/fendo.2023.1206368/fullmyelomabone metastatic tumorcomputed tomographymagnetic resonance imagingdiffusion weighted imagingpathology |
| spellingShingle | Hong Yu Shengnan Zhang Xiaohui Feng Feng Gao Multiple myeloma following bone metastasis of renal cell carcinoma: a case report Frontiers in Endocrinology myeloma bone metastatic tumor computed tomography magnetic resonance imaging diffusion weighted imaging pathology |
| title | Multiple myeloma following bone metastasis of renal cell carcinoma: a case report |
| title_full | Multiple myeloma following bone metastasis of renal cell carcinoma: a case report |
| title_fullStr | Multiple myeloma following bone metastasis of renal cell carcinoma: a case report |
| title_full_unstemmed | Multiple myeloma following bone metastasis of renal cell carcinoma: a case report |
| title_short | Multiple myeloma following bone metastasis of renal cell carcinoma: a case report |
| title_sort | multiple myeloma following bone metastasis of renal cell carcinoma a case report |
| topic | myeloma bone metastatic tumor computed tomography magnetic resonance imaging diffusion weighted imaging pathology |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1206368/full |
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