The Wound-Healing Activity of PEDOT-PSS in Animals
This study evaluated the wound-healing activity of a polymer, Poly(3,4-ethylenedioxythiophene):poly-(styrene sulfonate) (PEDOT: PSS), and determined its mechanism based on angiogenic activity in a full-thickness excision wound model in Spraque Dawley (SD) rats. Administering PEDOT: PSS (1.6) 1.5 ppm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/16/12539 |
| _version_ | 1797584475577647104 |
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| author | Yun-Lung Chung Pei-Yu Chou Ming-Jyh Sheu |
| author_facet | Yun-Lung Chung Pei-Yu Chou Ming-Jyh Sheu |
| author_sort | Yun-Lung Chung |
| collection | DOAJ |
| description | This study evaluated the wound-healing activity of a polymer, Poly(3,4-ethylenedioxythiophene):poly-(styrene sulfonate) (PEDOT: PSS), and determined its mechanism based on angiogenic activity in a full-thickness excision wound model in Spraque Dawley (SD) rats. Administering PEDOT: PSS (1.6) 1.5 ppm at a dose of 50 mg/kg/day significantly improved wound healing in the SD rats on the eleventh day after the incision was created. PEDOT: PSS-treated animals presented no anti-inflammatory skin effects; however, there was an increase in angiogenic behavior. VEGF was found to be significantly elevated in the PEDOT: PSS-treated groups seven days post-incision. However, only a higher concentration of PEDOT: PSS increased TGF-β1 expression within the same time frame. Our results showed that PEDOT: PSS enhances wound healing activity, mainly in terms of its angiogenic effects. In this paper, we describe the highly conductive macromolecular material PEDOT: PSS, which demonstrated accelerated wound-healing activity in the animal incision model. The results will further provide information regarding the application of PEDOT: PSS as a dressing for medical use. |
| first_indexed | 2024-03-10T23:53:12Z |
| format | Article |
| id | doaj.art-3b36aad0c8e14f609bbdf0aff66db6d7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T23:53:12Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-3b36aad0c8e14f609bbdf0aff66db6d72023-11-19T01:24:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-08-0124161253910.3390/ijms241612539The Wound-Healing Activity of PEDOT-PSS in AnimalsYun-Lung Chung0Pei-Yu Chou1Ming-Jyh Sheu2School of Pharmacy, College of Pharmacy, China Medical University, Taichung 406040, TaiwanDepartment of Nursing, National Chi Nan University, Nantou 54561, TaiwanSchool of Pharmacy, College of Pharmacy, China Medical University, Taichung 406040, TaiwanThis study evaluated the wound-healing activity of a polymer, Poly(3,4-ethylenedioxythiophene):poly-(styrene sulfonate) (PEDOT: PSS), and determined its mechanism based on angiogenic activity in a full-thickness excision wound model in Spraque Dawley (SD) rats. Administering PEDOT: PSS (1.6) 1.5 ppm at a dose of 50 mg/kg/day significantly improved wound healing in the SD rats on the eleventh day after the incision was created. PEDOT: PSS-treated animals presented no anti-inflammatory skin effects; however, there was an increase in angiogenic behavior. VEGF was found to be significantly elevated in the PEDOT: PSS-treated groups seven days post-incision. However, only a higher concentration of PEDOT: PSS increased TGF-β1 expression within the same time frame. Our results showed that PEDOT: PSS enhances wound healing activity, mainly in terms of its angiogenic effects. In this paper, we describe the highly conductive macromolecular material PEDOT: PSS, which demonstrated accelerated wound-healing activity in the animal incision model. The results will further provide information regarding the application of PEDOT: PSS as a dressing for medical use.https://www.mdpi.com/1422-0067/24/16/12539wound-healingangiogenesisVEGFTGF-β1 |
| spellingShingle | Yun-Lung Chung Pei-Yu Chou Ming-Jyh Sheu The Wound-Healing Activity of PEDOT-PSS in Animals International Journal of Molecular Sciences wound-healing angiogenesis VEGF TGF-β1 |
| title | The Wound-Healing Activity of PEDOT-PSS in Animals |
| title_full | The Wound-Healing Activity of PEDOT-PSS in Animals |
| title_fullStr | The Wound-Healing Activity of PEDOT-PSS in Animals |
| title_full_unstemmed | The Wound-Healing Activity of PEDOT-PSS in Animals |
| title_short | The Wound-Healing Activity of PEDOT-PSS in Animals |
| title_sort | wound healing activity of pedot pss in animals |
| topic | wound-healing angiogenesis VEGF TGF-β1 |
| url | https://www.mdpi.com/1422-0067/24/16/12539 |
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