Strategies for Delivery of siRNAs to Ovarian Cancer Cells
The unmet need for novel therapeutic options for ovarian cancer (OC) deserves further investigation. Among the different novel drugs, small interfering RNAs (siRNAs) are particularly attractive because of their specificity of action and efficacy, as documented in many experimental setups. However, t...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/10/547 |
| _version_ | 1828136158311219200 |
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| author | Rossella Farra Matea Maruna Francesca Perrone Mario Grassi Fabio Benedetti Marianna Maddaloni Maguie El Boustani Salvo Parisi Flavio Rizzolio Giancarlo Forte Fabrizio Zanconati Maja Cemazar Urska Kamensek Barbara Dapas Gabriele Grassi |
| author_facet | Rossella Farra Matea Maruna Francesca Perrone Mario Grassi Fabio Benedetti Marianna Maddaloni Maguie El Boustani Salvo Parisi Flavio Rizzolio Giancarlo Forte Fabrizio Zanconati Maja Cemazar Urska Kamensek Barbara Dapas Gabriele Grassi |
| author_sort | Rossella Farra |
| collection | DOAJ |
| description | The unmet need for novel therapeutic options for ovarian cancer (OC) deserves further investigation. Among the different novel drugs, small interfering RNAs (siRNAs) are particularly attractive because of their specificity of action and efficacy, as documented in many experimental setups. However, the fragility of these molecules in the biological environment necessitates the use of delivery materials able to protect them and possibly target them to the cancer cells. Among the different delivery materials, those based on polymers and lipids are considered very interesting because of their biocompatibility and ability to carry/deliver siRNAs. Despite these features, polymers and lipids need to be engineered to optimize their delivery properties for OC. In this review, we concentrated on the description of the therapeutic potential of siRNAs and polymer-/lipid-based delivery systems for OC. After a brief description of OC and siRNA features, we summarized the strategies employed to minimize siRNA delivery problems, the targeting strategies to OC, and the preclinical models available. Finally, we discussed the most interesting works published in the last three years about polymer-/lipid-based materials for siRNA delivery. |
| first_indexed | 2024-04-11T17:58:25Z |
| format | Article |
| id | doaj.art-3b375c75ea73465e80818a3b526cc03d |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T17:58:25Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-3b375c75ea73465e80818a3b526cc03d2022-12-22T04:10:35ZengMDPI AGPharmaceutics1999-49232019-10-01111054710.3390/pharmaceutics11100547pharmaceutics11100547Strategies for Delivery of siRNAs to Ovarian Cancer CellsRossella Farra0Matea Maruna1Francesca Perrone2Mario Grassi3Fabio Benedetti4Marianna Maddaloni5Maguie El Boustani6Salvo Parisi7Flavio Rizzolio8Giancarlo Forte9Fabrizio Zanconati10Maja Cemazar11Urska Kamensek12Barbara Dapas13Gabriele Grassi14Department of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyDepartment of Engineering and Architecture, University of Trieste, Via Valerio 6/A, I-34127 Trieste, ItalyDipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, I-34127 Trieste, ItalyDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyPathology Unit, IRCCS CRO Aviano-National Cancer Institute, I-33081 Aviano, ItalyPathology Unit, IRCCS CRO Aviano-National Cancer Institute, I-33081 Aviano, ItalyPathology Unit, IRCCS CRO Aviano-National Cancer Institute, I-33081 Aviano, ItalyInternational Clinical Research Center (ICRC), St Anne’s University Hospital, CZ-65691 Brno, Czech RepublicDepartment of Medical, Surgical and Health Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume, 447, I-34149 Trieste, ItalyDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Zaloska 2, SI-1000 Ljubljana, SloveniaFaculty of Health Sciences, University of Primorska, Polje 42, SI-6310 Izola, SloveniaDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyDepartment of Life Sciences, Cattinara University Hospital, Trieste University, Strada di Fiume 447, I-34149 Trieste, ItalyThe unmet need for novel therapeutic options for ovarian cancer (OC) deserves further investigation. Among the different novel drugs, small interfering RNAs (siRNAs) are particularly attractive because of their specificity of action and efficacy, as documented in many experimental setups. However, the fragility of these molecules in the biological environment necessitates the use of delivery materials able to protect them and possibly target them to the cancer cells. Among the different delivery materials, those based on polymers and lipids are considered very interesting because of their biocompatibility and ability to carry/deliver siRNAs. Despite these features, polymers and lipids need to be engineered to optimize their delivery properties for OC. In this review, we concentrated on the description of the therapeutic potential of siRNAs and polymer-/lipid-based delivery systems for OC. After a brief description of OC and siRNA features, we summarized the strategies employed to minimize siRNA delivery problems, the targeting strategies to OC, and the preclinical models available. Finally, we discussed the most interesting works published in the last three years about polymer-/lipid-based materials for siRNA delivery.https://www.mdpi.com/1999-4923/11/10/547ovarian cancersirnapolymerlipiddelivery |
| spellingShingle | Rossella Farra Matea Maruna Francesca Perrone Mario Grassi Fabio Benedetti Marianna Maddaloni Maguie El Boustani Salvo Parisi Flavio Rizzolio Giancarlo Forte Fabrizio Zanconati Maja Cemazar Urska Kamensek Barbara Dapas Gabriele Grassi Strategies for Delivery of siRNAs to Ovarian Cancer Cells Pharmaceutics ovarian cancer sirna polymer lipid delivery |
| title | Strategies for Delivery of siRNAs to Ovarian Cancer Cells |
| title_full | Strategies for Delivery of siRNAs to Ovarian Cancer Cells |
| title_fullStr | Strategies for Delivery of siRNAs to Ovarian Cancer Cells |
| title_full_unstemmed | Strategies for Delivery of siRNAs to Ovarian Cancer Cells |
| title_short | Strategies for Delivery of siRNAs to Ovarian Cancer Cells |
| title_sort | strategies for delivery of sirnas to ovarian cancer cells |
| topic | ovarian cancer sirna polymer lipid delivery |
| url | https://www.mdpi.com/1999-4923/11/10/547 |
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