[b][/b]The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlanders
Background. The stimuli acting on a person in a high mountain environment (such as hypobaric hypoxia with subsequent reoxygenation, physical exercise) can significantly increase oxidative stress, stimulate erythropoiesis, lead to changes in the blood count and participate in the development of altit...
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| Format: | Article |
| Language: | English |
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Institute of Rural Health
2014-09-01
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| Series: | Annals of Agricultural and Environmental Medicine |
| Subjects: | |
| Online Access: | http://journals.indexcopernicus.com/fulltxt.php?ICID=1120607 |
| _version_ | 1818380394400055296 |
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| author | Jakub Krzeszowiak Marcin Zawadzki Iwona Markiewicz-Górka Agata Kawalec Krystyna Pawlas |
| author_facet | Jakub Krzeszowiak Marcin Zawadzki Iwona Markiewicz-Górka Agata Kawalec Krystyna Pawlas |
| author_sort | Jakub Krzeszowiak |
| collection | DOAJ |
| description | Background. The stimuli acting on a person in a high mountain environment (such as hypobaric hypoxia with subsequent reoxygenation, physical exercise) can significantly increase oxidative stress, stimulate erythropoiesis, lead to changes in the blood count and participate in the development of altitude sickness.
[b]Objective. [/b]The aim was to investigate changes in haematological parameters, indicators of oxidative stress (malondialdehyde – MDA) and antioxidant defences: catalase (CAT), superoxide dismutase (SOD), and total antioxidant status (TAS) in the plasma of young, healthy people after a 9-day expedition in the Alps.
[b]Materials and method[/b]. A total of 5 patients (4 men and 1 woman), members of the Wrocław Mountaineering Club, aged 24–26 years. Collection of blood samples was carried out immediately before departure and 3 days after the end of exposure to high-altitude conditions. During the expedition, the subjects were exposed to heights: 2,050–4,165 m.a.s.l., and exercise associated with climbing.
[b]Results[/b]. Trekking in the Alps neither caused significant changes in the parameters of red blood cells nor increased the level of oxidative stress parameters in plasma. CAT activity increased, the ratio of SOD / CAT decreased. There was also a decrease in the total number of leukocytes, mainly monocytes and basophils.
[b]Conclusions[/b]. 9-day exposure to high-altitude conditions is not a substantial burden for the organism of young, physically active people. The increase in antioxidant capacity is sufficient to stop oxidative processes, which are severe in these conditions, and to prevent the occurrence of significant oxidative stress. Discontinuation of exposure to allergens and dust pollution clears the airways, which is indicated by the reduction in the number of monocytes and basophils. |
| first_indexed | 2024-12-14T02:17:59Z |
| format | Article |
| id | doaj.art-3b3995f778d14ca6869a936d5aed58c3 |
| institution | Directory Open Access Journal |
| issn | 1232-1966 1898-2263 |
| language | English |
| last_indexed | 2024-12-14T02:17:59Z |
| publishDate | 2014-09-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Annals of Agricultural and Environmental Medicine |
| spelling | doaj.art-3b3995f778d14ca6869a936d5aed58c32022-12-21T23:20:35ZengInstitute of Rural HealthAnnals of Agricultural and Environmental Medicine1232-19661898-22632014-09-0121875194585589[b][/b]The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlandersJakub Krzeszowiak0Marcin Zawadzki1Iwona Markiewicz-Górka2Agata Kawalec3Krystyna Pawlas4Department of Hygiene, Medical University, Wroclaw, Poland Department of Forensic Medicine, Medical University, Wroclaw, PolandDepartment of Hygiene, Medical University, Wroclaw, PolandDepartment of Hygiene, Medical University, Wroclaw, PolandDepartment of Hygiene, Medical University, Wroclaw, PolandBackground. The stimuli acting on a person in a high mountain environment (such as hypobaric hypoxia with subsequent reoxygenation, physical exercise) can significantly increase oxidative stress, stimulate erythropoiesis, lead to changes in the blood count and participate in the development of altitude sickness. [b]Objective. [/b]The aim was to investigate changes in haematological parameters, indicators of oxidative stress (malondialdehyde – MDA) and antioxidant defences: catalase (CAT), superoxide dismutase (SOD), and total antioxidant status (TAS) in the plasma of young, healthy people after a 9-day expedition in the Alps. [b]Materials and method[/b]. A total of 5 patients (4 men and 1 woman), members of the Wrocław Mountaineering Club, aged 24–26 years. Collection of blood samples was carried out immediately before departure and 3 days after the end of exposure to high-altitude conditions. During the expedition, the subjects were exposed to heights: 2,050–4,165 m.a.s.l., and exercise associated with climbing. [b]Results[/b]. Trekking in the Alps neither caused significant changes in the parameters of red blood cells nor increased the level of oxidative stress parameters in plasma. CAT activity increased, the ratio of SOD / CAT decreased. There was also a decrease in the total number of leukocytes, mainly monocytes and basophils. [b]Conclusions[/b]. 9-day exposure to high-altitude conditions is not a substantial burden for the organism of young, physically active people. The increase in antioxidant capacity is sufficient to stop oxidative processes, which are severe in these conditions, and to prevent the occurrence of significant oxidative stress. Discontinuation of exposure to allergens and dust pollution clears the airways, which is indicated by the reduction in the number of monocytes and basophils.http://journals.indexcopernicus.com/fulltxt.php?ICID=1120607High-altitude environment;Blood count;Oxidative Stress |
| spellingShingle | Jakub Krzeszowiak Marcin Zawadzki Iwona Markiewicz-Górka Agata Kawalec Krystyna Pawlas [b][/b]The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlanders Annals of Agricultural and Environmental Medicine High-altitude environment;Blood count;Oxidative Stress |
| title | [b][/b]The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlanders |
| title_full | [b][/b]The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlanders |
| title_fullStr | [b][/b]The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlanders |
| title_full_unstemmed | [b][/b]The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlanders |
| title_short | [b][/b]The influence of 9-day trekking in the Alps on the level of oxidative stress parameters and blood parameters in native lowlanders |
| title_sort | b b the influence of 9 day trekking in the alps on the level of oxidative stress parameters and blood parameters in native lowlanders |
| topic | High-altitude environment;Blood count;Oxidative Stress |
| url | http://journals.indexcopernicus.com/fulltxt.php?ICID=1120607 |
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