Synergistic Effect Of Simvastatin And Romidepsin On Gamma-Globin Gene Induction

Synergistic Effect Of Simvastatin And Romidepsin On Gamma-Globin Gene Induction

Objective Hemoglobinopathies such as beta-thalassemia and sickle cell disease (SCD) are inherited disorders that are caused by mutations in beta-globin chain. Gamma-globin gene reactivation can ameliorate clinical manifestations of beta- thalassemia and SCD. Drugs that induce fetal hemoglobin (HbF)...

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Bibliographic Details
Main Authors: Hussain Habibi, Amir Atashi, Saeid Abroun, Mehrdad Noruzinia
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2018-08-01
Series:Cell Journal
Subjects:
Beta-Thalassemia
Romidepsin
Sickle Cell Disease
Simvastatin
Online Access:https://celljournal.org/journal/article/abstract/5589

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