Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction

Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction

Summary: Background: Clonal haematopoiesis driven by mutations in DNMT3A or TET2 has recently been identified as a new risk factor for cardiovascular disease. Experimental studies suggest that these mutations may enhance inflammation which accelerates the disease progression. We aim to investigate...

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Bibliographic Details
Main Authors: Shengfang Wang, Sining Hu, Xing Luo, Xiaoyi Bao, Ji Li, Minghao Liu, Ying Lv, Chen Zhao, Ming Zeng, Xi Chen, Amanda Unsworth, Sarah Jones, Thomas W. Johnson, Stephen J. White, Haibo Jia, Bo Yu
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:EBioMedicine
Subjects:
Clonal hematopoiesis
Myocardial infarction
DNMT3A/TET2
Prognosis
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422001487

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