Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig
SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of AC...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16048-4 |
| _version_ | 1818716902856327168 |
|---|---|
| author | Changhai Lei Kewen Qian Tian Li Sheng Zhang Wenyan Fu Min Ding Shi Hu |
| author_facet | Changhai Lei Kewen Qian Tian Li Sheng Zhang Wenyan Fu Min Ding Shi Hu |
| author_sort | Changhai Lei |
| collection | DOAJ |
| description | SARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of ACE2-Ig in mice. |
| first_indexed | 2024-12-17T19:26:39Z |
| format | Article |
| id | doaj.art-3b3d05e197724b28bed5fc76756f4d1d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T19:26:39Z |
| publishDate | 2020-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3b3d05e197724b28bed5fc76756f4d1d2022-12-21T21:35:21ZengNature PortfolioNature Communications2041-17232020-04-011111510.1038/s41467-020-16048-4Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-IgChanghai Lei0Kewen Qian1Tian Li2Sheng Zhang3Wenyan Fu4Min Ding5Shi Hu6Department of Biophysics, College of Basic Medical Sciences, Second Military Medical UniversityDepartment of Biophysics, College of Basic Medical Sciences, Second Military Medical UniversityDepartment of Biophysics, College of Basic Medical Sciences, Second Military Medical UniversityDepartment of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Assisted Reproduction, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of MedicinePharchoice Therapeutics, IncDepartment of Biophysics, College of Basic Medical Sciences, Second Military Medical UniversitySARS-CoV-2 uses ACE2 as the entry receptor. Here, the authors show that an ACE2-Ig fusion protein inhibits entry of virus pseudotyped with the SARS-CoV-2 spike protein, show differential binding kinetics of SARS-CoV and SARSCoV-2 spike proteins to ACE2, and determine pharmakocinetic parameters of ACE2-Ig in mice.https://doi.org/10.1038/s41467-020-16048-4 |
| spellingShingle | Changhai Lei Kewen Qian Tian Li Sheng Zhang Wenyan Fu Min Ding Shi Hu Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig Nature Communications |
| title | Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig |
| title_full | Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig |
| title_fullStr | Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig |
| title_full_unstemmed | Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig |
| title_short | Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig |
| title_sort | neutralization of sars cov 2 spike pseudotyped virus by recombinant ace2 ig |
| url | https://doi.org/10.1038/s41467-020-16048-4 |
| work_keys_str_mv | AT changhailei neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig AT kewenqian neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig AT tianli neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig AT shengzhang neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig AT wenyanfu neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig AT minding neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig AT shihu neutralizationofsarscov2spikepseudotypedvirusbyrecombinantace2ig |