A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect

A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect

A novel 4/8 subtype α-conotoxin, Vt1.27 (NCCMFHTCPIDYSRFNC-NH2), was identified from Conus vitulinus in the South China Sea by RACE methods. The peptide was synthesized and structurally characterized. Similar to other α-conotoxins that target neuronal nicotinic acetylcholine receptor (nAChR) subtype...

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Bibliographic Details
Main Authors: Shuo Wang, Peter Bartels, Cong Zhao, Arsalan Yousuf, Zhuguo Liu, Shuo Yu, Anuja R. Bony, Xiaoli Ma, Qin Dai, Ting Sun, Na Liu, Mengke Yang, Rilei Yu, Weihong Du, David J. Adams, Qiuyun Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
Conus vitulinus
α-conotoxin Vt1.27
N-type calcium channels
nicotinic acethylcholine receptor
electrophysiology
anti-allodynic effect
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.881732/full

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