Mechanisms Responsible for the Trophic Effect of Beta-Adrenoceptors on the Ito Current Density in Type 1 Diabetic Rat Cardiomyocytes

Mechanisms Responsible for the Trophic Effect of Beta-Adrenoceptors on the Ito Current Density in Type 1 Diabetic Rat Cardiomyocytes

Background/Aims: In diabetic ventricular myocytes, transient outward potassium current (Ito) amplitude is severely reduced because of the impaired catecholamine release that characterizes diabetic autonomic neuropathy. Sympathetic nervous system exhibits a trophic effect on Ito since incubation of m...

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Bibliographic Details
Main Authors: Raúl Setién, Aintzane Alday, Cristina Diaz-Asensio, Janire Urrutia, Mónica Gallego, Oscar Casis
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Repolarization
Adrenergic
Arrhythmia
Arrestin
G protein
Online Access:http://www.karger.com/Article/FullText/343346

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