Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (<i>Tursiops truncatus</i>)
Stimulation of the thyroid with thyroid-stimulating hormone (TSH) is a potentially useful diagnostic of thyroid dysfunction, but little is known about the response of the thyroid to TSH stimulation in bottlenose dolphins (<i>Tursiops truncatus</i>). To better characterize the response of...
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MDPI AG
2021-05-01
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| Series: | Journal of Zoological and Botanical Gardens |
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| Online Access: | https://www.mdpi.com/2673-5636/2/2/18 |
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| author | Dorian S. Houser Cory Champagne Daniel E. Crocker |
| author_facet | Dorian S. Houser Cory Champagne Daniel E. Crocker |
| author_sort | Dorian S. Houser |
| collection | DOAJ |
| description | Stimulation of the thyroid with thyroid-stimulating hormone (TSH) is a potentially useful diagnostic of thyroid dysfunction, but little is known about the response of the thyroid to TSH stimulation in bottlenose dolphins (<i>Tursiops truncatus</i>). To better characterize the response of the dolphin thyroid to TSH stimulation, five adult dolphins participated in a TSH stimulation study. Dolphins voluntarily beached onto a padded mat and were given a 1.5 mg intramuscular injection of human recombinant TSH. Blood samples collected the day prior, at multiple intervals the day of, and daily for three days after the injection were analyzed via radioimmunoassay for free and total triiodothyronine (fT3 and tT3), and free and total thyroxine (fT4 and tT4). Significant increases in circulating fT3, fT4, and tT4 were observed with peaks occurring for all hormones the day after the TSH injection; maximal increases were 44%, 47%, and 23% for each hormone, respectively. Temporal patterns in the hormones potentially reflected feedback mechanisms countering the surge in fT3 following stimulation. Though recombinant human TSH was effective at stimulating hormone release, it is likely that use of dolphin or dolphin-derived TSH would enhance the clinical utility of the stimulation test, as would the development of antibodies specific to dolphin TSH. |
| first_indexed | 2024-03-10T09:50:38Z |
| format | Article |
| id | doaj.art-3b456d355a9a4364a197dd61c8c8b55c |
| institution | Directory Open Access Journal |
| issn | 2673-5636 |
| language | English |
| last_indexed | 2024-03-10T09:50:38Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Zoological and Botanical Gardens |
| spelling | doaj.art-3b456d355a9a4364a197dd61c8c8b55c2023-11-22T02:43:57ZengMDPI AGJournal of Zoological and Botanical Gardens2673-56362021-05-012226527210.3390/jzbg2020018Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (<i>Tursiops truncatus</i>)Dorian S. Houser0Cory Champagne1Daniel E. Crocker2National Marine Mammal Foundation, 2240 Shelter Island Drive, Suite 200, San Diego, CA 92106, USANational Marine Mammal Foundation, 2240 Shelter Island Drive, Suite 200, San Diego, CA 92106, USADepartment of Biology, Sonoma State University, 1801 East Cotati Avenue, Rohnert Park, CA 94928, USAStimulation of the thyroid with thyroid-stimulating hormone (TSH) is a potentially useful diagnostic of thyroid dysfunction, but little is known about the response of the thyroid to TSH stimulation in bottlenose dolphins (<i>Tursiops truncatus</i>). To better characterize the response of the dolphin thyroid to TSH stimulation, five adult dolphins participated in a TSH stimulation study. Dolphins voluntarily beached onto a padded mat and were given a 1.5 mg intramuscular injection of human recombinant TSH. Blood samples collected the day prior, at multiple intervals the day of, and daily for three days after the injection were analyzed via radioimmunoassay for free and total triiodothyronine (fT3 and tT3), and free and total thyroxine (fT4 and tT4). Significant increases in circulating fT3, fT4, and tT4 were observed with peaks occurring for all hormones the day after the TSH injection; maximal increases were 44%, 47%, and 23% for each hormone, respectively. Temporal patterns in the hormones potentially reflected feedback mechanisms countering the surge in fT3 following stimulation. Though recombinant human TSH was effective at stimulating hormone release, it is likely that use of dolphin or dolphin-derived TSH would enhance the clinical utility of the stimulation test, as would the development of antibodies specific to dolphin TSH.https://www.mdpi.com/2673-5636/2/2/18thyroid stimulationthyroxinetriiodothyroninecetacean |
| spellingShingle | Dorian S. Houser Cory Champagne Daniel E. Crocker Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (<i>Tursiops truncatus</i>) Journal of Zoological and Botanical Gardens thyroid stimulation thyroxine triiodothyronine cetacean |
| title | Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_full | Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_fullStr | Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_full_unstemmed | Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_short | Thyroid-Stimulating Hormone Stimulation Tests in the Bottlenose Dolphin (<i>Tursiops truncatus</i>) |
| title_sort | thyroid stimulating hormone stimulation tests in the bottlenose dolphin i tursiops truncatus i |
| topic | thyroid stimulation thyroxine triiodothyronine cetacean |
| url | https://www.mdpi.com/2673-5636/2/2/18 |
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