Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories.
BACKGROUND/OBJECTIVES:Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely a...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2019-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0214784 |
| _version_ | 1818403721531359232 |
|---|---|
| author | Mandip S Dhamoon Ying-Kuen Cheung Yeseon P Moon Clinton B Wright Ralph L Sacco Mitchell S V Elkind |
| author_facet | Mandip S Dhamoon Ying-Kuen Cheung Yeseon P Moon Clinton B Wright Ralph L Sacco Mitchell S V Elkind |
| author_sort | Mandip S Dhamoon |
| collection | DOAJ |
| description | BACKGROUND/OBJECTIVES:Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up. DESIGN:Prospective population based cohort study. SETTING:The Northern Manhattan Study. PARTICIPANTS (INCLUDING THE SAMPLE SIZE):Race/ethnically diverse stroke-free individuals in northern Manhattan aged ≥40 years (n = 3298). INTERVENTION:None. MEASUREMENTS:Annual functional assessments with the Barthel index (BI), for a median of 13 years. BI was analyzed as a continuous variable (range 0-100). Baseline demographics, risk factors, and laboratory studies were collected, including IL6 (n = 1679), LpPLA2 mass (n = 1912) and activity (n = 1937). Separate mixed models estimated standardized associations between each biomarker and baseline functional status and change over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. RESULTS:Mean age was 69 (SD 10) years, 35% were male, 53% Hispanic, 74% hypertensive, and 16-24% diabetic. LogIL6 was associated with decline in BI over time (-0.13 points per year, 95% CI -0.24, -0.02) and marginally with baseline BI (-0.20, 95% CI -0.40, 0.01). LpPLA2 activity levels were associated with baseline BI (-0.36, 95% CI -0.68, -0.04) but not change over time, and LpPLA2 mass levels were not associated with either. CONCLUSION:In this large population-based study, higher serum inflammatory biomarker levels were associated with disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up. |
| first_indexed | 2024-12-14T08:28:46Z |
| format | Article |
| id | doaj.art-3b46cd119b424ef58d6a5d625bd1f8c5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T08:28:46Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3b46cd119b424ef58d6a5d625bd1f8c52022-12-21T23:09:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01144e021478410.1371/journal.pone.0214784Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories.Mandip S DhamoonYing-Kuen CheungYeseon P MoonClinton B WrightRalph L SaccoMitchell S V ElkindBACKGROUND/OBJECTIVES:Inflammatory biomarkers have been associated with stroke and mortality, but inflammation may also have detrimental effects beyond acute events. We hypothesized that serum concentrations of interleukin-6 (IL6) and lipoprotein-associated phospholipase A2 (LpPLA2) were inversely associated with long-term functional decline independently of vascular risk factors, stroke and myocardial infarction (MI) occurring during follow-up. DESIGN:Prospective population based cohort study. SETTING:The Northern Manhattan Study. PARTICIPANTS (INCLUDING THE SAMPLE SIZE):Race/ethnically diverse stroke-free individuals in northern Manhattan aged ≥40 years (n = 3298). INTERVENTION:None. MEASUREMENTS:Annual functional assessments with the Barthel index (BI), for a median of 13 years. BI was analyzed as a continuous variable (range 0-100). Baseline demographics, risk factors, and laboratory studies were collected, including IL6 (n = 1679), LpPLA2 mass (n = 1912) and activity (n = 1937). Separate mixed models estimated standardized associations between each biomarker and baseline functional status and change over time, adjusting for demographics, vascular risk factors, social variables, cognition, and depression measured at baseline, and stroke and MI occurring during follow-up. RESULTS:Mean age was 69 (SD 10) years, 35% were male, 53% Hispanic, 74% hypertensive, and 16-24% diabetic. LogIL6 was associated with decline in BI over time (-0.13 points per year, 95% CI -0.24, -0.02) and marginally with baseline BI (-0.20, 95% CI -0.40, 0.01). LpPLA2 activity levels were associated with baseline BI (-0.36, 95% CI -0.68, -0.04) but not change over time, and LpPLA2 mass levels were not associated with either. CONCLUSION:In this large population-based study, higher serum inflammatory biomarker levels were associated with disability, even when adjusting for baseline covariates and stroke and MI occurring during follow-up.https://doi.org/10.1371/journal.pone.0214784 |
| spellingShingle | Mandip S Dhamoon Ying-Kuen Cheung Yeseon P Moon Clinton B Wright Ralph L Sacco Mitchell S V Elkind Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. PLoS ONE |
| title | Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. |
| title_full | Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. |
| title_fullStr | Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. |
| title_full_unstemmed | Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. |
| title_short | Interleukin-6 and lipoprotein-associated phospholipase A2 are associated with functional trajectories. |
| title_sort | interleukin 6 and lipoprotein associated phospholipase a2 are associated with functional trajectories |
| url | https://doi.org/10.1371/journal.pone.0214784 |
| work_keys_str_mv | AT mandipsdhamoon interleukin6andlipoproteinassociatedphospholipasea2areassociatedwithfunctionaltrajectories AT yingkuencheung interleukin6andlipoproteinassociatedphospholipasea2areassociatedwithfunctionaltrajectories AT yeseonpmoon interleukin6andlipoproteinassociatedphospholipasea2areassociatedwithfunctionaltrajectories AT clintonbwright interleukin6andlipoproteinassociatedphospholipasea2areassociatedwithfunctionaltrajectories AT ralphlsacco interleukin6andlipoproteinassociatedphospholipasea2areassociatedwithfunctionaltrajectories AT mitchellsvelkind interleukin6andlipoproteinassociatedphospholipasea2areassociatedwithfunctionaltrajectories |