Antimicrobial Resistance Determinants in Genomes and Plasmids from <i>Acinetobacter baumannii</i> Clinical Isolates
<i>Acinetobacter baumannii</i> is a Gram-negative coccoid rod species, clinically relevant as a human pathogen, included in the ESKAPE group. Carbapenem-resistant <i>A. baumannii</i> (CRAB) are considered by the World Health Organization (WHO) as a critical priority pathogen...
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MDPI AG
2021-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/7/753 |
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| author | Itziar Chapartegui-González María Lázaro-Díez Santiago Redondo-Salvo Jesús Navas José Ramos-Vivas |
| author_facet | Itziar Chapartegui-González María Lázaro-Díez Santiago Redondo-Salvo Jesús Navas José Ramos-Vivas |
| author_sort | Itziar Chapartegui-González |
| collection | DOAJ |
| description | <i>Acinetobacter baumannii</i> is a Gram-negative coccoid rod species, clinically relevant as a human pathogen, included in the ESKAPE group. Carbapenem-resistant <i>A. baumannii</i> (CRAB) are considered by the World Health Organization (WHO) as a critical priority pathogen for the research and development of new antibiotics. Some of the most relevant features of this pathogen are its intrinsic multidrug resistance and its ability to acquire rapid and effective new resistant determinants against last-resort clinical antibiotics, mostly from other ESKAPE species. The presence of plasmids and mobile genetic elements in their genomes contributes to the acquisition of new antimicrobial resistance determinants. However, although <i>A. baumannii</i> has arisen as an important human pathogen, information about these elements is still not well understood. Current genomic analysis availability has increased our ability to understand the microevolution of bacterial pathogens, including point mutations, genetic dissemination, genomic stability, and pan- and core-genome compositions. In this work, we deeply studied the genomes of four clinical strains from our hospital, and the reference strain ATCC<sup>®</sup>19606<sup>TM</sup>, which have shown a remarkable ability to survive and maintain their effective capacity when subjected to long-term stress conditions. With that, our aim was presenting a detailed analysis of their genomes, including antibiotic resistance determinants and plasmid composition. |
| first_indexed | 2024-03-10T10:11:30Z |
| format | Article |
| id | doaj.art-3b4878aaead1495581f5bc544f8f33b5 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T10:11:30Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-3b4878aaead1495581f5bc544f8f33b52023-11-22T01:10:24ZengMDPI AGAntibiotics2079-63822021-06-0110775310.3390/antibiotics10070753Antimicrobial Resistance Determinants in Genomes and Plasmids from <i>Acinetobacter baumannii</i> Clinical IsolatesItziar Chapartegui-González0María Lázaro-Díez1Santiago Redondo-Salvo2Jesús Navas3José Ramos-Vivas4Department of Microbiology and Immunology, UTMB, Galveston, TX 77550, USAInstituto de Agrobiotecnología, CSIC-Gobierno de Navarra, 31192 Mutilva, SpainInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC, 39011 Santander, SpainGrupo BIOMEDAGE, Facultad de Medicina, Universidad de Cantabria, 39011 Santander, SpainResearch Group on Foods, Nutritional Biochemistry and Health, Universidad Europea del Atlántico, 39011 Santander, Spain<i>Acinetobacter baumannii</i> is a Gram-negative coccoid rod species, clinically relevant as a human pathogen, included in the ESKAPE group. Carbapenem-resistant <i>A. baumannii</i> (CRAB) are considered by the World Health Organization (WHO) as a critical priority pathogen for the research and development of new antibiotics. Some of the most relevant features of this pathogen are its intrinsic multidrug resistance and its ability to acquire rapid and effective new resistant determinants against last-resort clinical antibiotics, mostly from other ESKAPE species. The presence of plasmids and mobile genetic elements in their genomes contributes to the acquisition of new antimicrobial resistance determinants. However, although <i>A. baumannii</i> has arisen as an important human pathogen, information about these elements is still not well understood. Current genomic analysis availability has increased our ability to understand the microevolution of bacterial pathogens, including point mutations, genetic dissemination, genomic stability, and pan- and core-genome compositions. In this work, we deeply studied the genomes of four clinical strains from our hospital, and the reference strain ATCC<sup>®</sup>19606<sup>TM</sup>, which have shown a remarkable ability to survive and maintain their effective capacity when subjected to long-term stress conditions. With that, our aim was presenting a detailed analysis of their genomes, including antibiotic resistance determinants and plasmid composition.https://www.mdpi.com/2079-6382/10/7/753<i>Acinetobacter baumannii</i>ESKAPE pathogensantimicrobial determinantsplasmidsbioinformaticsWGS |
| spellingShingle | Itziar Chapartegui-González María Lázaro-Díez Santiago Redondo-Salvo Jesús Navas José Ramos-Vivas Antimicrobial Resistance Determinants in Genomes and Plasmids from <i>Acinetobacter baumannii</i> Clinical Isolates Antibiotics <i>Acinetobacter baumannii</i> ESKAPE pathogens antimicrobial determinants plasmids bioinformatics WGS |
| title | Antimicrobial Resistance Determinants in Genomes and Plasmids from <i>Acinetobacter baumannii</i> Clinical Isolates |
| title_full | Antimicrobial Resistance Determinants in Genomes and Plasmids from <i>Acinetobacter baumannii</i> Clinical Isolates |
| title_fullStr | Antimicrobial Resistance Determinants in Genomes and Plasmids from <i>Acinetobacter baumannii</i> Clinical Isolates |
| title_full_unstemmed | Antimicrobial Resistance Determinants in Genomes and Plasmids from <i>Acinetobacter baumannii</i> Clinical Isolates |
| title_short | Antimicrobial Resistance Determinants in Genomes and Plasmids from <i>Acinetobacter baumannii</i> Clinical Isolates |
| title_sort | antimicrobial resistance determinants in genomes and plasmids from i acinetobacter baumannii i clinical isolates |
| topic | <i>Acinetobacter baumannii</i> ESKAPE pathogens antimicrobial determinants plasmids bioinformatics WGS |
| url | https://www.mdpi.com/2079-6382/10/7/753 |
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