Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.
Real-time shear wave elastography (2D-SWE) is a two-dimensional transient elastography and a competitor as a biomarker of liver fibrosis in comparison with the standard reference transient elastography by M probe (TE-M). The aims were to compare several criteria of applicability, and to assess infla...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5051706?pdf=render |
| _version_ | 1819207710710693888 |
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| author | Thierry Poynard Tam Pham Hugo Perazzo Mona Munteanu Elena Luckina Djamel Elaribi Yen Ngo Luminita Bonyhay Noemie Seurat Muriel Legroux An Ngo Olivier Deckmyn Dominique Thabut Vlad Ratziu Olivier Lucidarme FIBROFRANCE-HECAM |
| author_facet | Thierry Poynard Tam Pham Hugo Perazzo Mona Munteanu Elena Luckina Djamel Elaribi Yen Ngo Luminita Bonyhay Noemie Seurat Muriel Legroux An Ngo Olivier Deckmyn Dominique Thabut Vlad Ratziu Olivier Lucidarme FIBROFRANCE-HECAM |
| author_sort | Thierry Poynard |
| collection | DOAJ |
| description | Real-time shear wave elastography (2D-SWE) is a two-dimensional transient elastography and a competitor as a biomarker of liver fibrosis in comparison with the standard reference transient elastography by M probe (TE-M). The aims were to compare several criteria of applicability, and to assess inflammation and steatosis impact on elasticity values, two unmet needs.We took FibroTest as the fibrosis reference and ActiTest and SteatoTest as quantitative estimates of inflammation and steatosis. After standardization of estimates, analyses used curve fitting, quantitative Lin concordance coefficient [LCC], and multivariate logistic regression.A total of 2,251 consecutive patients were included. We validated the predetermined 0.2 kPa cut-off as a too low minimal elasticity value identifying not-reliable 2D-SWE results (LCC with FibroTest = 0.0281[-0.119;0.175]. Other criteria, elasticity CV, body mass index and depth of measures were not sufficiently discriminant. The applicability of 2D-SWE (95%CI) 89.6%(88.2-90.8), was significantly higher than that of TE, 85.6%(84.0-87.0; P<0.0001). In patients with non-advanced fibrosis (METAVIR F0F1F2), elasticity values estimated by 2D-SWE was less impacted by inflammation and steatosis than elasticity value estimated by TE-M: LCC (95%CI) 0.039 (0.021;0.058) vs 0.090 (0.068;0.112;P<0.01) and 0.105 (0.068;0.141) vs 0.192 (0.153;0.230; P<0.01) respectively. The three analyses methods gave similar results.Elasticity results including very low minimal signal in the region of interest should be considered not reliable. 2D-SWE had a higher applicability than TE, the reference elastography, with less impact of inflammation and steatosis especially in patients with non-advanced fibrosis, as presumed by blood tests.ClinicalTrials.gov NCT01927133. |
| first_indexed | 2024-12-23T05:27:49Z |
| format | Article |
| id | doaj.art-3b48d39209e9440f87ffdbcebfea576c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T05:27:49Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3b48d39209e9440f87ffdbcebfea576c2022-12-21T17:58:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016327610.1371/journal.pone.0163276Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison.Thierry PoynardTam PhamHugo PerazzoMona MunteanuElena LuckinaDjamel ElaribiYen NgoLuminita BonyhayNoemie SeuratMuriel LegrouxAn NgoOlivier DeckmynDominique ThabutVlad RatziuOlivier LucidarmeFIBROFRANCE-HECAMReal-time shear wave elastography (2D-SWE) is a two-dimensional transient elastography and a competitor as a biomarker of liver fibrosis in comparison with the standard reference transient elastography by M probe (TE-M). The aims were to compare several criteria of applicability, and to assess inflammation and steatosis impact on elasticity values, two unmet needs.We took FibroTest as the fibrosis reference and ActiTest and SteatoTest as quantitative estimates of inflammation and steatosis. After standardization of estimates, analyses used curve fitting, quantitative Lin concordance coefficient [LCC], and multivariate logistic regression.A total of 2,251 consecutive patients were included. We validated the predetermined 0.2 kPa cut-off as a too low minimal elasticity value identifying not-reliable 2D-SWE results (LCC with FibroTest = 0.0281[-0.119;0.175]. Other criteria, elasticity CV, body mass index and depth of measures were not sufficiently discriminant. The applicability of 2D-SWE (95%CI) 89.6%(88.2-90.8), was significantly higher than that of TE, 85.6%(84.0-87.0; P<0.0001). In patients with non-advanced fibrosis (METAVIR F0F1F2), elasticity values estimated by 2D-SWE was less impacted by inflammation and steatosis than elasticity value estimated by TE-M: LCC (95%CI) 0.039 (0.021;0.058) vs 0.090 (0.068;0.112;P<0.01) and 0.105 (0.068;0.141) vs 0.192 (0.153;0.230; P<0.01) respectively. The three analyses methods gave similar results.Elasticity results including very low minimal signal in the region of interest should be considered not reliable. 2D-SWE had a higher applicability than TE, the reference elastography, with less impact of inflammation and steatosis especially in patients with non-advanced fibrosis, as presumed by blood tests.ClinicalTrials.gov NCT01927133.http://europepmc.org/articles/PMC5051706?pdf=render |
| spellingShingle | Thierry Poynard Tam Pham Hugo Perazzo Mona Munteanu Elena Luckina Djamel Elaribi Yen Ngo Luminita Bonyhay Noemie Seurat Muriel Legroux An Ngo Olivier Deckmyn Dominique Thabut Vlad Ratziu Olivier Lucidarme FIBROFRANCE-HECAM Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison. PLoS ONE |
| title | Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison. |
| title_full | Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison. |
| title_fullStr | Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison. |
| title_full_unstemmed | Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison. |
| title_short | Real-Time Shear Wave versus Transient Elastography for Predicting Fibrosis: Applicability, and Impact of Inflammation and Steatosis. A Non-Invasive Comparison. |
| title_sort | real time shear wave versus transient elastography for predicting fibrosis applicability and impact of inflammation and steatosis a non invasive comparison |
| url | http://europepmc.org/articles/PMC5051706?pdf=render |
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