Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting
Human gut and food microbiomes interact during digestion. The outcome of these interactions influences the taxonomical composition and functional capacity of the resident human gut microbiome, with potential consequential impacts on health and disease. Microbe-microbe interactions between the reside...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1002185/full |
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| author | A. Kate Falà A. Kate Falà A. Kate Falà Avelino Álvarez-Ordóñez Alain Filloux Cormac G. M. Gahan Cormac G. M. Gahan Cormac G. M. Gahan Paul D. Cotter Paul D. Cotter |
| author_facet | A. Kate Falà A. Kate Falà A. Kate Falà Avelino Álvarez-Ordóñez Alain Filloux Cormac G. M. Gahan Cormac G. M. Gahan Cormac G. M. Gahan Paul D. Cotter Paul D. Cotter |
| author_sort | A. Kate Falà |
| collection | DOAJ |
| description | Human gut and food microbiomes interact during digestion. The outcome of these interactions influences the taxonomical composition and functional capacity of the resident human gut microbiome, with potential consequential impacts on health and disease. Microbe-microbe interactions between the resident and introduced microbiomes, which likely influence host colonisation, are orchestrated by environmental conditions, elements of the food matrix, host-associated factors as well as social cues from other microorganisms. Quorum sensing is one example of a social cue that allows bacterial communities to regulate genetic expression based on their respective population density and has emerged as an attractive target for therapeutic intervention. By interfering with bacterial quorum sensing, for instance, enzymatic degradation of signalling molecules (quorum quenching) or the application of quorum sensing inhibitory compounds, it may be possible to modulate the microbial composition of communities of interest without incurring negative effects associated with traditional antimicrobial approaches. In this review, we summarise and critically discuss the literature relating to quorum sensing from the perspective of the interactions between the food and human gut microbiome, providing a general overview of the current understanding of the prevalence and influence of quorum sensing in this context, and assessing the potential for therapeutic targeting of quorum sensing mechanisms. |
| first_indexed | 2024-04-11T07:44:58Z |
| format | Article |
| id | doaj.art-3b4920976614427bb15d0c663dcb5995 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-11T07:44:58Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-3b4920976614427bb15d0c663dcb59952022-12-22T04:36:21ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-11-011310.3389/fmicb.2022.10021851002185Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targetingA. Kate Falà0A. Kate Falà1A. Kate Falà2Avelino Álvarez-Ordóñez3Alain Filloux4Cormac G. M. Gahan5Cormac G. M. Gahan6Cormac G. M. Gahan7Paul D. Cotter8Paul D. Cotter9APC Microbiome Ireland, University College Cork, Cork, IrelandSchool of Microbiology, University College Cork, Cork, IrelandFood Bioscience Department, Teagasc Food Research Centre, Fermoy, IrelandDepartment of Food Hygiene and Technology and Institute of Food Science and Technology, Universidad de León, León, SpainMRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Imperial College London, London, United KingdomAPC Microbiome Ireland, University College Cork, Cork, IrelandSchool of Microbiology, University College Cork, Cork, IrelandSchool of Pharmacy, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandFood Bioscience Department, Teagasc Food Research Centre, Fermoy, IrelandHuman gut and food microbiomes interact during digestion. The outcome of these interactions influences the taxonomical composition and functional capacity of the resident human gut microbiome, with potential consequential impacts on health and disease. Microbe-microbe interactions between the resident and introduced microbiomes, which likely influence host colonisation, are orchestrated by environmental conditions, elements of the food matrix, host-associated factors as well as social cues from other microorganisms. Quorum sensing is one example of a social cue that allows bacterial communities to regulate genetic expression based on their respective population density and has emerged as an attractive target for therapeutic intervention. By interfering with bacterial quorum sensing, for instance, enzymatic degradation of signalling molecules (quorum quenching) or the application of quorum sensing inhibitory compounds, it may be possible to modulate the microbial composition of communities of interest without incurring negative effects associated with traditional antimicrobial approaches. In this review, we summarise and critically discuss the literature relating to quorum sensing from the perspective of the interactions between the food and human gut microbiome, providing a general overview of the current understanding of the prevalence and influence of quorum sensing in this context, and assessing the potential for therapeutic targeting of quorum sensing mechanisms.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1002185/fullquorum sensingquorum quenchingquorum sensing inhibitiongut microbiomefood microbiomefood matrix |
| spellingShingle | A. Kate Falà A. Kate Falà A. Kate Falà Avelino Álvarez-Ordóñez Alain Filloux Cormac G. M. Gahan Cormac G. M. Gahan Cormac G. M. Gahan Paul D. Cotter Paul D. Cotter Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting Frontiers in Microbiology quorum sensing quorum quenching quorum sensing inhibition gut microbiome food microbiome food matrix |
| title | Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting |
| title_full | Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting |
| title_fullStr | Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting |
| title_full_unstemmed | Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting |
| title_short | Quorum sensing in human gut and food microbiomes: Significance and potential for therapeutic targeting |
| title_sort | quorum sensing in human gut and food microbiomes significance and potential for therapeutic targeting |
| topic | quorum sensing quorum quenching quorum sensing inhibition gut microbiome food microbiome food matrix |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1002185/full |
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