Microenvironment–A Role in Tumour Progression and Prognosis
In addition to malignant cells, solid tumours comprise supporting stromal tissue that consists of Extra Cellular Matrix (ECM), connective tissue cells, inflammatory cells and blood vessels. The stromal compartment and the malignant cells together shape the tumour microenvironment that in turn dete...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2013-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/3419/83-%206619_E(%20_%20)_PF1(%20_%20)_F(H)_PF1(VH)_PFA(NC)_OLF.pdf |
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| author | Jaya Nagendra Krishna Muppalla Keerthi Muddana Shyam Prasad Reddy Dorankula Madhusudan Rao Thokala Ajay Prakash Pasupula |
| author_facet | Jaya Nagendra Krishna Muppalla Keerthi Muddana Shyam Prasad Reddy Dorankula Madhusudan Rao Thokala Ajay Prakash Pasupula |
| author_sort | Jaya Nagendra Krishna Muppalla |
| collection | DOAJ |
| description | In addition to malignant cells, solid tumours comprise supporting stromal tissue that consists of Extra Cellular Matrix (ECM), connective tissue
cells, inflammatory cells and blood vessels. The stromal compartment and the malignant cells together shape the tumour microenvironment
that in turn determines tumour progression and efficacy of anti-tumour treatments. It is now recognized that the host microenvironment
undergoes extensive change during the evolution and progression of cancer. This involves the generation of Tumour-Associated Fibroblasts
(TAFs), which, through release of growth factors and cytokines, lead to enhanced angiogenesis, increased tumour growth and invasion.
It has also been demonstrated that TAFs may modulate the Cancer Stem Cell (CSC) phenotype, which has therapeutic implications.
Understanding the various components in the tumour microenvironment may afford us the opportunity to develop new drugs that target
these reversible nonmutational events in the prevention and treatment of cancer. |
| first_indexed | 2024-12-11T08:55:53Z |
| format | Article |
| id | doaj.art-3b49ffaeb8894563896ac2a6eecb8750 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T08:55:53Z |
| publishDate | 2013-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-3b49ffaeb8894563896ac2a6eecb87502022-12-22T01:13:53ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-09-01792096209910.7860/JCDR/2013/6619.3419Microenvironment–A Role in Tumour Progression and PrognosisJaya Nagendra Krishna Muppalla0Keerthi Muddana1Shyam Prasad Reddy Dorankula2Madhusudan Rao Thokala3Ajay Prakash Pasupula4Senior lecturer, Department of Endodontics & Conservative Dentistry, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda (dt), Andhra Pradesh, India.Senior lecturer, Department of Oral & MaxilloFacial Pathology, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda (dt), Andhra Pradesh, India.Senior lecturer, Department of Oral & MaxilloFacial Pathology, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda (dt), Andhra Pradesh, India.Reader , Department of Oral & MaxilloFacial Pathology, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda (dt), Andhra Pradesh, India.Professor & HOD , Department of Oral & MaxilloFacial Pathology, Kamineni Institute of Dental Sciences, Narketpally, Nalgonda (dt), Andhra Pradesh, Inida.In addition to malignant cells, solid tumours comprise supporting stromal tissue that consists of Extra Cellular Matrix (ECM), connective tissue cells, inflammatory cells and blood vessels. The stromal compartment and the malignant cells together shape the tumour microenvironment that in turn determines tumour progression and efficacy of anti-tumour treatments. It is now recognized that the host microenvironment undergoes extensive change during the evolution and progression of cancer. This involves the generation of Tumour-Associated Fibroblasts (TAFs), which, through release of growth factors and cytokines, lead to enhanced angiogenesis, increased tumour growth and invasion. It has also been demonstrated that TAFs may modulate the Cancer Stem Cell (CSC) phenotype, which has therapeutic implications. Understanding the various components in the tumour microenvironment may afford us the opportunity to develop new drugs that target these reversible nonmutational events in the prevention and treatment of cancer.https://jcdr.net/articles/PDF/3419/83-%206619_E(%20_%20)_PF1(%20_%20)_F(H)_PF1(VH)_PFA(NC)_OLF.pdfextra cellular matrixtumour associated fibroblastscytokinescancer stem cells |
| spellingShingle | Jaya Nagendra Krishna Muppalla Keerthi Muddana Shyam Prasad Reddy Dorankula Madhusudan Rao Thokala Ajay Prakash Pasupula Microenvironment–A Role in Tumour Progression and Prognosis Journal of Clinical and Diagnostic Research extra cellular matrix tumour associated fibroblasts cytokines cancer stem cells |
| title | Microenvironment–A Role in Tumour Progression and Prognosis |
| title_full | Microenvironment–A Role in Tumour Progression and Prognosis |
| title_fullStr | Microenvironment–A Role in Tumour Progression and Prognosis |
| title_full_unstemmed | Microenvironment–A Role in Tumour Progression and Prognosis |
| title_short | Microenvironment–A Role in Tumour Progression and Prognosis |
| title_sort | microenvironment a role in tumour progression and prognosis |
| topic | extra cellular matrix tumour associated fibroblasts cytokines cancer stem cells |
| url | https://jcdr.net/articles/PDF/3419/83-%206619_E(%20_%20)_PF1(%20_%20)_F(H)_PF1(VH)_PFA(NC)_OLF.pdf |
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