Statin Hepatotoxicity: Is it a Real Concern?
Statins are the most effective and widely used drugs for treating dyslipidemia, a major risk factor for coronary heart disease. These are one of the safest hypolipidemic drugs but many patients are advised to discontinue statins for the fear of hepatotoxicity. Despite a lack of evidence that statins...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Heart Views |
| Subjects: | |
| Online Access: | http://www.heartviews.org/article.asp?issn=1995-705X;year=2011;volume=12;issue=3;spage=104;epage=106;aulast=Sikka |
| _version_ | 1819130705000529920 |
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| author | Pranav Sikka K K Saxena Seema Kapoor |
| author_facet | Pranav Sikka K K Saxena Seema Kapoor |
| author_sort | Pranav Sikka |
| collection | DOAJ |
| description | Statins are the most effective and widely used drugs for treating dyslipidemia, a major risk factor for coronary heart disease. These are one of the safest hypolipidemic drugs but many patients are advised to discontinue statins for the fear of hepatotoxicity. Despite a lack of evidence that statins cause liver diseases, many physicians are reluctant to start statins in patients with an out-of-range liver enzymes value and this reluctance to initiate or interrupt the therapy with statins leads to dyslipidemia and its grave consequences. Further, there are some reports showing an additional benefit of statins in reducing cardiovascular events in patients with abnormal liver function tests. |
| first_indexed | 2024-12-22T09:03:51Z |
| format | Article |
| id | doaj.art-3b4aa5c7efb94663b01f62359e450afb |
| institution | Directory Open Access Journal |
| issn | 1995-705X |
| language | English |
| last_indexed | 2024-12-22T09:03:51Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Heart Views |
| spelling | doaj.art-3b4aa5c7efb94663b01f62359e450afb2022-12-21T18:31:39ZengWolters Kluwer Medknow PublicationsHeart Views1995-705X2011-01-0112310410610.4103/1995-705X.95065Statin Hepatotoxicity: Is it a Real Concern?Pranav SikkaK K SaxenaSeema KapoorStatins are the most effective and widely used drugs for treating dyslipidemia, a major risk factor for coronary heart disease. These are one of the safest hypolipidemic drugs but many patients are advised to discontinue statins for the fear of hepatotoxicity. Despite a lack of evidence that statins cause liver diseases, many physicians are reluctant to start statins in patients with an out-of-range liver enzymes value and this reluctance to initiate or interrupt the therapy with statins leads to dyslipidemia and its grave consequences. Further, there are some reports showing an additional benefit of statins in reducing cardiovascular events in patients with abnormal liver function tests.http://www.heartviews.org/article.asp?issn=1995-705X;year=2011;volume=12;issue=3;spage=104;epage=106;aulast=SikkaDyslipidemiahepatotoxicitystatins |
| spellingShingle | Pranav Sikka K K Saxena Seema Kapoor Statin Hepatotoxicity: Is it a Real Concern? Heart Views Dyslipidemia hepatotoxicity statins |
| title | Statin Hepatotoxicity: Is it a Real Concern? |
| title_full | Statin Hepatotoxicity: Is it a Real Concern? |
| title_fullStr | Statin Hepatotoxicity: Is it a Real Concern? |
| title_full_unstemmed | Statin Hepatotoxicity: Is it a Real Concern? |
| title_short | Statin Hepatotoxicity: Is it a Real Concern? |
| title_sort | statin hepatotoxicity is it a real concern |
| topic | Dyslipidemia hepatotoxicity statins |
| url | http://www.heartviews.org/article.asp?issn=1995-705X;year=2011;volume=12;issue=3;spage=104;epage=106;aulast=Sikka |
| work_keys_str_mv | AT pranavsikka statinhepatotoxicityisitarealconcern AT kksaxena statinhepatotoxicityisitarealconcern AT seemakapoor statinhepatotoxicityisitarealconcern |