Comprehensive enhancer-target gene assignments improve gene set level interpretation of genome-wide regulatory data

Comprehensive enhancer-target gene assignments improve gene set level interpretation of genome-wide regulatory data

Abstract Background Revealing the gene targets of distal regulatory elements is challenging yet critical for interpreting regulome data. Experiment-derived enhancer-gene links are restricted to a small set of enhancers and/or cell types, while the accuracy of genome-wide approaches remains elusive d...

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Bibliographic Details
Main Authors: Tingting Qin, Christopher Lee, Shiting Li, Raymond G. Cavalcante, Peter Orchard, Heming Yao, Hanrui Zhang, Shuze Wang, Snehal Patil, Alan P. Boyle, Maureen A. Sartor
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Genome Biology
Subjects:
Enhancer
Target gene
Gene Ontology
Gene set enrichment test
Genomic regions
ChIP-seq
Online Access:https://doi.org/10.1186/s13059-022-02668-0

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