A Mechanosensitive Channel, Mouse Transmembrane Channel-Like Protein 1 (mTMC1) Is Translated from a Splice Variant <i>mTmc1ex1</i> but Not from the Other Variant <i>mTmc1ex2</i>

A Mechanosensitive Channel, Mouse Transmembrane Channel-Like Protein 1 (mTMC1) Is Translated from a Splice Variant <i>mTmc1ex1</i> but Not from the Other Variant <i>mTmc1ex2</i>

Mechanical stimuli caused by sound waves are detected by hair cells in the cochlea through the opening of mechanoelectrical transduction (MET) channels. Transmembrane channel-like protein 1 (TMC1) has been revealed to be the pore-forming component of the MET channel. The two splice variants for mous...

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Bibliographic Details
Main Authors: Soichiro Yamaguchi, Maho Hamamura, Ken-ichi Otsuguro
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Tmc1</i>
mechanosensitive channel
translation
upstream open reading frame
Kozak sequence
Online Access:https://www.mdpi.com/1422-0067/21/18/6465

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