Cerebral metastasis from osteosarcoma: “Bone” in the brain
Although brain metastases from bone and soft tissue sarcoma are uncommon, advances in sarcoma treatment have led to an increasing incidence of them. We present a 23-year-old male with a history of metastatic femoral osteosarcoma, who presented with headache and unsteady gait and was diagnosed with a...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Radiology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S193004332030100X |
| _version_ | 1818773090563260416 |
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| author | Stefania Kokkali, MD, MSc Efthymios Andriotis, MD Elena Katsarou, MD Angelos Theocharis, MD Maria Drizou, MD, MSc Elpida Magou, MD Alexandros Tzovaras, MD, PhD Alexandros Ardavanis, MD, PhD |
| author_facet | Stefania Kokkali, MD, MSc Efthymios Andriotis, MD Elena Katsarou, MD Angelos Theocharis, MD Maria Drizou, MD, MSc Elpida Magou, MD Alexandros Tzovaras, MD, PhD Alexandros Ardavanis, MD, PhD |
| author_sort | Stefania Kokkali, MD, MSc |
| collection | DOAJ |
| description | Although brain metastases from bone and soft tissue sarcoma are uncommon, advances in sarcoma treatment have led to an increasing incidence of them. We present a 23-year-old male with a history of metastatic femoral osteosarcoma, who presented with headache and unsteady gait and was diagnosed with a cerebellar metastasis. CT scan revealed a mass in the left cerebellar parenchyma with large intralesional central calcification and perilesional edema. Corticosteroid treatment led to neurological symptoms resolution, with a rapid tapering. The patient had also lung metastases and we opted to administer systemic treatment with the tyrosine kinase inhibitor cabozantinib. Given the relative radioresistance of osteosarcomas, the patient did not receive radiation therapy. |
| first_indexed | 2024-12-18T10:19:43Z |
| format | Article |
| id | doaj.art-3b54a5eaee66428c8a9c229c691de03c |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-12-18T10:19:43Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-3b54a5eaee66428c8a9c229c691de03c2022-12-21T21:11:10ZengElsevierRadiology Case Reports1930-04332020-06-01156780783Cerebral metastasis from osteosarcoma: “Bone” in the brainStefania Kokkali, MD, MSc0Efthymios Andriotis, MD1Elena Katsarou, MD2Angelos Theocharis, MD3Maria Drizou, MD, MSc4Elpida Magou, MD5Alexandros Tzovaras, MD, PhD6Alexandros Ardavanis, MD, PhD7First Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, Greece; Corresponding author.Radiology Department, Saint-Savvas Cancer Hospital, Athens, GreeceFirst Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, GreeceFirst Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, GreeceFirst Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, GreeceFirst Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, GreeceFirst Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, GreeceFirst Medical Oncology Clinic, Saint-Savvas Cancer Hospital, L. Alexandras 171, 11522 Athens, GreeceAlthough brain metastases from bone and soft tissue sarcoma are uncommon, advances in sarcoma treatment have led to an increasing incidence of them. We present a 23-year-old male with a history of metastatic femoral osteosarcoma, who presented with headache and unsteady gait and was diagnosed with a cerebellar metastasis. CT scan revealed a mass in the left cerebellar parenchyma with large intralesional central calcification and perilesional edema. Corticosteroid treatment led to neurological symptoms resolution, with a rapid tapering. The patient had also lung metastases and we opted to administer systemic treatment with the tyrosine kinase inhibitor cabozantinib. Given the relative radioresistance of osteosarcomas, the patient did not receive radiation therapy.http://www.sciencedirect.com/science/article/pii/S193004332030100XBrain metastasisOsteosarcomaCalcification |
| spellingShingle | Stefania Kokkali, MD, MSc Efthymios Andriotis, MD Elena Katsarou, MD Angelos Theocharis, MD Maria Drizou, MD, MSc Elpida Magou, MD Alexandros Tzovaras, MD, PhD Alexandros Ardavanis, MD, PhD Cerebral metastasis from osteosarcoma: “Bone” in the brain Radiology Case Reports Brain metastasis Osteosarcoma Calcification |
| title | Cerebral metastasis from osteosarcoma: “Bone” in the brain |
| title_full | Cerebral metastasis from osteosarcoma: “Bone” in the brain |
| title_fullStr | Cerebral metastasis from osteosarcoma: “Bone” in the brain |
| title_full_unstemmed | Cerebral metastasis from osteosarcoma: “Bone” in the brain |
| title_short | Cerebral metastasis from osteosarcoma: “Bone” in the brain |
| title_sort | cerebral metastasis from osteosarcoma bone in the brain |
| topic | Brain metastasis Osteosarcoma Calcification |
| url | http://www.sciencedirect.com/science/article/pii/S193004332030100X |
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