Comorbidity increases the risk of pulmonary tuberculosis: a nested case-control study using multi-source big data
Abstract Background Some medical conditions may increase the risk of developing pulmonary tuberculosis (PTB); however, no systematic study on PTB-associated comorbidities and comorbidity clusters has been undertaken. Methods A nested case-control study was conducted from 2013 to 2017 using multi-sou...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-023-02817-6 |
| _version_ | 1797355975626194944 |
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| author | Bao-Yu Wang Ke Song Hai-Tao Wang Shan-Shan Wang Wen-Jing Wang Zhen-Wei Li Wan-Yu Du Fu-Zhong Xue Lin Zhao Wu-Chun Cao |
| author_facet | Bao-Yu Wang Ke Song Hai-Tao Wang Shan-Shan Wang Wen-Jing Wang Zhen-Wei Li Wan-Yu Du Fu-Zhong Xue Lin Zhao Wu-Chun Cao |
| author_sort | Bao-Yu Wang |
| collection | DOAJ |
| description | Abstract Background Some medical conditions may increase the risk of developing pulmonary tuberculosis (PTB); however, no systematic study on PTB-associated comorbidities and comorbidity clusters has been undertaken. Methods A nested case-control study was conducted from 2013 to 2017 using multi-source big data. We defined cases as patients with incident PTB, and we matched each case with four event-free controls using propensity score matching (PSM). Comorbidities diagnosed prior to PTB were defined with the International Classification of Diseases-10 (ICD-10). The longitudinal relationships between multimorbidity burden and PTB were analyzed using a generalized estimating equation. The associations between PTB and 30 comorbidities were examined using conditional logistic regression, and the comorbidity clusters were identified using network analysis. Results A total of 4265 cases and 17,060 controls were enrolled during the study period. A total of 849 (19.91%) cases and 1141 (6.69%) controls were multimorbid before the index date. Having 1, 2, and ≥ 3 comorbidities was associated with an increased risk of PTB (aOR 2.85–5.16). Fourteen out of thirty comorbidities were significantly associated with PTB (aOR 1.28–7.27), and the associations differed by sex and age. Network analysis identified three major clusters, mainly in the respiratory, circulatory, and endocrine/metabolic systems, in PTB cases. Conclusions Certain comorbidities involving multiple systems may significantly increase the risk of PTB. Enhanced awareness and surveillance of comorbidity are warranted to ensure early prevention and timely control of PTB. |
| first_indexed | 2024-03-08T14:19:59Z |
| format | Article |
| id | doaj.art-3b54e9c37fdd45ceafe411b172139105 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-08T14:19:59Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-3b54e9c37fdd45ceafe411b1721391052024-01-14T12:07:27ZengBMCBMC Pulmonary Medicine1471-24662024-01-0124111010.1186/s12890-023-02817-6Comorbidity increases the risk of pulmonary tuberculosis: a nested case-control study using multi-source big dataBao-Yu Wang0Ke Song1Hai-Tao Wang2Shan-Shan Wang3Wen-Jing Wang4Zhen-Wei Li5Wan-Yu Du6Fu-Zhong Xue7Lin Zhao8Wu-Chun Cao9Institute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong UniversityInstitute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong UniversityInstitute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong UniversityInstitute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong UniversityInstitute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong UniversityInstitute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong UniversityInstitute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong UniversityInstitute of EcoHealth, School of Public Health, Cheeloo College of Medicine, Shandong UniversityAbstract Background Some medical conditions may increase the risk of developing pulmonary tuberculosis (PTB); however, no systematic study on PTB-associated comorbidities and comorbidity clusters has been undertaken. Methods A nested case-control study was conducted from 2013 to 2017 using multi-source big data. We defined cases as patients with incident PTB, and we matched each case with four event-free controls using propensity score matching (PSM). Comorbidities diagnosed prior to PTB were defined with the International Classification of Diseases-10 (ICD-10). The longitudinal relationships between multimorbidity burden and PTB were analyzed using a generalized estimating equation. The associations between PTB and 30 comorbidities were examined using conditional logistic regression, and the comorbidity clusters were identified using network analysis. Results A total of 4265 cases and 17,060 controls were enrolled during the study period. A total of 849 (19.91%) cases and 1141 (6.69%) controls were multimorbid before the index date. Having 1, 2, and ≥ 3 comorbidities was associated with an increased risk of PTB (aOR 2.85–5.16). Fourteen out of thirty comorbidities were significantly associated with PTB (aOR 1.28–7.27), and the associations differed by sex and age. Network analysis identified three major clusters, mainly in the respiratory, circulatory, and endocrine/metabolic systems, in PTB cases. Conclusions Certain comorbidities involving multiple systems may significantly increase the risk of PTB. Enhanced awareness and surveillance of comorbidity are warranted to ensure early prevention and timely control of PTB.https://doi.org/10.1186/s12890-023-02817-6Pulmonary TuberculosisComorbidityMultimorbidityPreventionNested case-control study |
| spellingShingle | Bao-Yu Wang Ke Song Hai-Tao Wang Shan-Shan Wang Wen-Jing Wang Zhen-Wei Li Wan-Yu Du Fu-Zhong Xue Lin Zhao Wu-Chun Cao Comorbidity increases the risk of pulmonary tuberculosis: a nested case-control study using multi-source big data BMC Pulmonary Medicine Pulmonary Tuberculosis Comorbidity Multimorbidity Prevention Nested case-control study |
| title | Comorbidity increases the risk of pulmonary tuberculosis: a nested case-control study using multi-source big data |
| title_full | Comorbidity increases the risk of pulmonary tuberculosis: a nested case-control study using multi-source big data |
| title_fullStr | Comorbidity increases the risk of pulmonary tuberculosis: a nested case-control study using multi-source big data |
| title_full_unstemmed | Comorbidity increases the risk of pulmonary tuberculosis: a nested case-control study using multi-source big data |
| title_short | Comorbidity increases the risk of pulmonary tuberculosis: a nested case-control study using multi-source big data |
| title_sort | comorbidity increases the risk of pulmonary tuberculosis a nested case control study using multi source big data |
| topic | Pulmonary Tuberculosis Comorbidity Multimorbidity Prevention Nested case-control study |
| url | https://doi.org/10.1186/s12890-023-02817-6 |
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