Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents
Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials and Methods:Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2016-03-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_6653_fc1f97ac4768490484eceb4df6c67814.pdf |
| _version_ | 1831740746024091648 |
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| author | Shokouhsadat Hamedi Mohammad Reza Shams-Ardakani Omid Sadeghpour Gholamreza Amin Dawood Hajighasemali Hossein Orafai |
| author_facet | Shokouhsadat Hamedi Mohammad Reza Shams-Ardakani Omid Sadeghpour Gholamreza Amin Dawood Hajighasemali Hossein Orafai |
| author_sort | Shokouhsadat Hamedi |
| collection | DOAJ |
| description | Objective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials and Methods:Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out.
Results: Discs showed excellent mucoadhesion and released high amount of the active ingredients (47%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity.
Conclusion:This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn’t follow the fick’s law. The water uptake and dissolution (DS), increased with the passing of time. |
| first_indexed | 2024-12-21T14:04:02Z |
| format | Article |
| id | doaj.art-3b564599d5df403d84113ac328d12c63 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-21T14:04:02Z |
| publishDate | 2016-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-3b564599d5df403d84113ac328d12c632022-12-21T19:01:17ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742016-03-011933303366653Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documentsShokouhsadat Hamedi0Mohammad Reza Shams-Ardakani1Omid Sadeghpour2Gholamreza Amin3Dawood Hajighasemali4Hossein Orafai5Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranHerbal Medicine Department, Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranFaculty of Traditional Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective (s): Mucoadhesive disc is one of the various routes of drug delivery for curing buccal disease.Materials and Methods:Everydiscs containing 70 mg stem bark extract of Ziziphus jujuba were formulated by using Carbopol 934, PVP k30 and gelatin as polymers. Discs were made by granulation and direct compression. Discs were standardized based on the total phenol. Properties such as in vitro and in vivo mucoadhesion, drug release, water uptake, and disintegration were carried out. Results: Discs showed excellent mucoadhesion and released high amount of the active ingredients (47%) immediately and completed after approximately the first hour. They had a good adhesion in buccal cavity. Conclusion:This study showed that the kinetics of release of the active substance from the mucoadhesive disc obeyed the zero order kinetic and didn’t follow the fick’s law. The water uptake and dissolution (DS), increased with the passing of time.http://ijbms.mums.ac.ir/article_6653_fc1f97ac4768490484eceb4df6c67814.pdfCarbopol 934Mucoadhesive discsPharmaceutical testsPVP(Polyvinylpyrrolidone)Ziziphus jujuba stem bark |
| spellingShingle | Shokouhsadat Hamedi Mohammad Reza Shams-Ardakani Omid Sadeghpour Gholamreza Amin Dawood Hajighasemali Hossein Orafai Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents Iranian Journal of Basic Medical Sciences Carbopol 934 Mucoadhesive discs Pharmaceutical tests PVP(Polyvinylpyrrolidone) Ziziphus jujuba stem bark |
| title | Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents |
| title_full | Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents |
| title_fullStr | Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents |
| title_full_unstemmed | Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents |
| title_short | Designing mucoadhesive discs containing stem bark extract of Ziziphus jujuba based on Iranian traditional documents |
| title_sort | designing mucoadhesive discs containing stem bark extract of ziziphus jujuba based on iranian traditional documents |
| topic | Carbopol 934 Mucoadhesive discs Pharmaceutical tests PVP(Polyvinylpyrrolidone) Ziziphus jujuba stem bark |
| url | http://ijbms.mums.ac.ir/article_6653_fc1f97ac4768490484eceb4df6c67814.pdf |
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