Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases

Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases

Abstract Background The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different next-generation sequencing (NGS) pipelines in paired cerebrospinal flui...

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Bibliographic Details
Main Authors: Mengxi Ge, Qiong Zhan, Zhenzhen Zhang, Xiaoyu Ji, Xinli Zhou, Ruofan Huang, Xiaohua Liang
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Cancer
Subjects:
Lung adenocarcinoma cancer
Leptomeningeal metastases
Cerebrospinal fluid
CSF cells
NGS pipelines
Online Access:http://link.springer.com/article/10.1186/s12885-019-5348-3

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