Optimizing MR-Guided Radiotherapy for Breast Cancer Patients

Optimizing MR-Guided Radiotherapy for Breast Cancer Patients

Current research in radiotherapy (RT) for breast cancer is evaluating neoadjuvant as opposed to adjuvant partial breast irradiation (PBI) with the aim of reducing the volume of breast tissue irradiated and therefore the risk of late treatment-related toxicity. The development of magnetic resonance (...

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Bibliographic Details
Main Authors: Maureen L. Groot Koerkamp, Jeanine E. Vasmel, Nicola S. Russell, Simona F. Shaitelman, Carmel N. Anandadas, Adam Currey, Danny Vesprini, Brian M. Keller, Chiara De-Colle, Kathy Han, Lior Z. Braunstein, Faisal Mahmood, Ebbe L. Lorenzen, Marielle E. P. Philippens, Helena M. Verkooijen, Jan J. W. Lagendijk, Antonetta C. Houweling, H. J. G. Desiree van den Bongard, Anna M. Kirby
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
breast cancer
neoadjuvant radiation therapy
partial breast irradiation
MR-guided radiotherapy
hybrid machine
MR-linac
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01107/full
Description
Summary:Current research in radiotherapy (RT) for breast cancer is evaluating neoadjuvant as opposed to adjuvant partial breast irradiation (PBI) with the aim of reducing the volume of breast tissue irradiated and therefore the risk of late treatment-related toxicity. The development of magnetic resonance (MR)–guided RT, including dedicated MR-guided RT systems [hybrid machines combining an MR scanner with a linear accelerator (MR-linac) or 60Co sources], could potentially reduce the irradiated volume even further by improving tumour visibility before and during each RT treatment. In this position paper, we discuss MR guidance in relation to each step of the breast RT planning and treatment pathway, focusing on the application of MR-guided RT to neoadjuvant PBI.
ISSN:2234-943X

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