Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus
A mixture of the benzofuran remirol and the benzopyran isoevodionol (5.7:1) was extracted by hydrodistillation from rhizomes of Mariscus pedunculatus. They were purified by successive thin layer chromatography. Their structure elucidation were confirmed by 2D-NMR experiments. The structure of remiro...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2001-01-01
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| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300006 |
| _version_ | 1818505833774841856 |
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| author | Siani Antonio C. Silva Ana M. P. Nakamura Marcos J. De Carvalho Márcia V. Henriques Maria G. M. O. Ramos Mônica F. S. Kaiser Carlos R. |
| author_facet | Siani Antonio C. Silva Ana M. P. Nakamura Marcos J. De Carvalho Márcia V. Henriques Maria G. M. O. Ramos Mônica F. S. Kaiser Carlos R. |
| author_sort | Siani Antonio C. |
| collection | DOAJ |
| description | A mixture of the benzofuran remirol and the benzopyran isoevodionol (5.7:1) was extracted by hydrodistillation from rhizomes of Mariscus pedunculatus. They were purified by successive thin layer chromatography. Their structure elucidation were confirmed by 2D-NMR experiments. The structure of remirol was also confirmed by its hydrogenation product. Crude distillate and the pure compounds were screened for anti-inflammatory activity by the use of the mouse pleurisy model induced by lipopolysaccharide (LPS, 12.5 ng/cavity). Both the mixture and remirol showed a dose-dependent (100 and 200 mg kg-1 p. o.) capacity to inhibit neutrophil and eosinophil accumulation in the mouse pleural cavity. In contrast, no anti-inflammatory effect was observed for iso-evodionol. |
| first_indexed | 2024-12-10T21:56:16Z |
| format | Article |
| id | doaj.art-3b570dc5d752492e8e64be6ffa3ad420 |
| institution | Directory Open Access Journal |
| issn | 0103-5053 |
| language | English |
| last_indexed | 2024-12-10T21:56:16Z |
| publishDate | 2001-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-3b570dc5d752492e8e64be6ffa3ad4202022-12-22T01:32:02ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50532001-01-01123354359Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatusSiani Antonio C.Silva Ana M. P.Nakamura Marcos J.De Carvalho Márcia V.Henriques Maria G. M. O.Ramos Mônica F. S.Kaiser Carlos R.A mixture of the benzofuran remirol and the benzopyran isoevodionol (5.7:1) was extracted by hydrodistillation from rhizomes of Mariscus pedunculatus. They were purified by successive thin layer chromatography. Their structure elucidation were confirmed by 2D-NMR experiments. The structure of remirol was also confirmed by its hydrogenation product. Crude distillate and the pure compounds were screened for anti-inflammatory activity by the use of the mouse pleurisy model induced by lipopolysaccharide (LPS, 12.5 ng/cavity). Both the mixture and remirol showed a dose-dependent (100 and 200 mg kg-1 p. o.) capacity to inhibit neutrophil and eosinophil accumulation in the mouse pleural cavity. In contrast, no anti-inflammatory effect was observed for iso-evodionol.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300006Mariscus pedunculatusbenzofuran derivativeremiroliso-evodionolanti-inflammatory activity |
| spellingShingle | Siani Antonio C. Silva Ana M. P. Nakamura Marcos J. De Carvalho Márcia V. Henriques Maria G. M. O. Ramos Mônica F. S. Kaiser Carlos R. Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus Journal of the Brazilian Chemical Society Mariscus pedunculatus benzofuran derivative remirol iso-evodionol anti-inflammatory activity |
| title | Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus |
| title_full | Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus |
| title_fullStr | Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus |
| title_full_unstemmed | Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus |
| title_short | Chemical composition and anti-inflammatory activity of the hydrodistillate from Mariscus pedunculatus |
| title_sort | chemical composition and anti inflammatory activity of the hydrodistillate from mariscus pedunculatus |
| topic | Mariscus pedunculatus benzofuran derivative remirol iso-evodionol anti-inflammatory activity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532001000300006 |
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