Randomized controlled trial of neurologic music therapy in Parkinson’s disease: research rehabilitation protocols for mechanistic and clinical investigations
Abstract Background Presently available medications and surgical treatments for Parkinson’s disease have limited effects on fine motor problems and often leave patients with significant fine motor disability. Standard of care occupational therapy (OT) yields low efficacy, potentially due to a lack o...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-08-01
|
| Series: | Trials |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13063-021-05560-7 |
| _version_ | 1818692644409180160 |
|---|---|
| author | Isabelle Buard Lucas Lattanzio Rebekah Stewart Sarah Thompson Kristin Sjoberg Karen Hookstadt Meghan Morrow Samantha K. Holden Stefan Sillau Michael Thaut Benzi Kluger |
| author_facet | Isabelle Buard Lucas Lattanzio Rebekah Stewart Sarah Thompson Kristin Sjoberg Karen Hookstadt Meghan Morrow Samantha K. Holden Stefan Sillau Michael Thaut Benzi Kluger |
| author_sort | Isabelle Buard |
| collection | DOAJ |
| description | Abstract Background Presently available medications and surgical treatments for Parkinson’s disease have limited effects on fine motor problems and often leave patients with significant fine motor disability. Standard of care occupational therapy (OT) yields low efficacy, potentially due to a lack of standard protocols. Neurologic music therapy (NMT) techniques, especially rhythmic auditory stimulation which relies on interaction between rhythm and movement, have shown to be effective in PD gait rehabilitation possibly through their reliance on neural pathways that are not affected by PD. Therapeutic instrumental music performance (TIMP) is one other NMT technique that holds promise but which mode of action and efficacy has not been investigated in PD yet. Methods One hundred PD participants will be randomly assigned to receive 15 sessions of either TIMP with rhythm or TIMP without rhythm, standard of care OT, or to be waitlisted (control) over 5 consecutive weeks. Brain oscillatory responses will be collected using magnetoencephalography during an auditory-motor task to understand the underlying mechanisms. The Grooved Pegboard, the UPDRS III finger tap, and the finger-thumb opposition will be assessed to investigate clinical changes related to fine motor function. This project will also serve to confirm or refute our pilot data findings suggesting NMT relies on compensatory brain networks utilized by the PD brain to bypass the dysfunctional basal ganglia. Discussion This study aims to use standardized TIMP and OT research protocols for investigating the neuronal pathways utilized by each intervention and possibly study their efficacy with respect to fine motor rehabilitation via a randomized control trial in the PD population. Trial registration ClinicalTrials.gov NCT03049033 . Registered on September 29, 2020 |
| first_indexed | 2024-12-17T13:01:04Z |
| format | Article |
| id | doaj.art-3b57528170bf4be8b6e5af5122cbf5b6 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-17T13:01:04Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-3b57528170bf4be8b6e5af5122cbf5b62022-12-21T21:47:22ZengBMCTrials1745-62152021-08-012211910.1186/s13063-021-05560-7Randomized controlled trial of neurologic music therapy in Parkinson’s disease: research rehabilitation protocols for mechanistic and clinical investigationsIsabelle Buard0Lucas Lattanzio1Rebekah Stewart2Sarah Thompson3Kristin Sjoberg4Karen Hookstadt5Meghan Morrow6Samantha K. Holden7Stefan Sillau8Michael Thaut9Benzi Kluger10Department of Neurology, University of Colorado DenverDepartment of Neurology, University of Colorado DenverRehabilitative RhythmsRehabilitative RhythmsRehabilitative RhythmsUniversity of Colorado HospitalUniversity of Colorado HospitalDepartment of Neurology, University of Colorado DenverDepartment of Neurology, University of Colorado DenverFaculty of Music, University of TorontoDepartment of Neurology, University of Rochester Medical CenterAbstract Background Presently available medications and surgical treatments for Parkinson’s disease have limited effects on fine motor problems and often leave patients with significant fine motor disability. Standard of care occupational therapy (OT) yields low efficacy, potentially due to a lack of standard protocols. Neurologic music therapy (NMT) techniques, especially rhythmic auditory stimulation which relies on interaction between rhythm and movement, have shown to be effective in PD gait rehabilitation possibly through their reliance on neural pathways that are not affected by PD. Therapeutic instrumental music performance (TIMP) is one other NMT technique that holds promise but which mode of action and efficacy has not been investigated in PD yet. Methods One hundred PD participants will be randomly assigned to receive 15 sessions of either TIMP with rhythm or TIMP without rhythm, standard of care OT, or to be waitlisted (control) over 5 consecutive weeks. Brain oscillatory responses will be collected using magnetoencephalography during an auditory-motor task to understand the underlying mechanisms. The Grooved Pegboard, the UPDRS III finger tap, and the finger-thumb opposition will be assessed to investigate clinical changes related to fine motor function. This project will also serve to confirm or refute our pilot data findings suggesting NMT relies on compensatory brain networks utilized by the PD brain to bypass the dysfunctional basal ganglia. Discussion This study aims to use standardized TIMP and OT research protocols for investigating the neuronal pathways utilized by each intervention and possibly study their efficacy with respect to fine motor rehabilitation via a randomized control trial in the PD population. Trial registration ClinicalTrials.gov NCT03049033 . Registered on September 29, 2020https://doi.org/10.1186/s13063-021-05560-7MagnetoencephalographyMotor cortical activityNeuronal entrainmentRehabilitationParkinson’s diseaseNeurologic music therapy |
| spellingShingle | Isabelle Buard Lucas Lattanzio Rebekah Stewart Sarah Thompson Kristin Sjoberg Karen Hookstadt Meghan Morrow Samantha K. Holden Stefan Sillau Michael Thaut Benzi Kluger Randomized controlled trial of neurologic music therapy in Parkinson’s disease: research rehabilitation protocols for mechanistic and clinical investigations Trials Magnetoencephalography Motor cortical activity Neuronal entrainment Rehabilitation Parkinson’s disease Neurologic music therapy |
| title | Randomized controlled trial of neurologic music therapy in Parkinson’s disease: research rehabilitation protocols for mechanistic and clinical investigations |
| title_full | Randomized controlled trial of neurologic music therapy in Parkinson’s disease: research rehabilitation protocols for mechanistic and clinical investigations |
| title_fullStr | Randomized controlled trial of neurologic music therapy in Parkinson’s disease: research rehabilitation protocols for mechanistic and clinical investigations |
| title_full_unstemmed | Randomized controlled trial of neurologic music therapy in Parkinson’s disease: research rehabilitation protocols for mechanistic and clinical investigations |
| title_short | Randomized controlled trial of neurologic music therapy in Parkinson’s disease: research rehabilitation protocols for mechanistic and clinical investigations |
| title_sort | randomized controlled trial of neurologic music therapy in parkinson s disease research rehabilitation protocols for mechanistic and clinical investigations |
| topic | Magnetoencephalography Motor cortical activity Neuronal entrainment Rehabilitation Parkinson’s disease Neurologic music therapy |
| url | https://doi.org/10.1186/s13063-021-05560-7 |
| work_keys_str_mv | AT isabellebuard randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT lucaslattanzio randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT rebekahstewart randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT sarahthompson randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT kristinsjoberg randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT karenhookstadt randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT meghanmorrow randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT samanthakholden randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT stefansillau randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT michaelthaut randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations AT benzikluger randomizedcontrolledtrialofneurologicmusictherapyinparkinsonsdiseaseresearchrehabilitationprotocolsformechanisticandclinicalinvestigations |