Biomedical application of photo-crosslinked gelatin hydrogels
Abstract During the past decades, photo-crosslinked gelatin hydrogel (methacrylated gelatin, GelMA) has gained a lot of attention due to its remarkable application in the biomedical field. It has been widely used in cell transplantation, cell culture and drug delivery, based on its crosslinking to f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-02-01
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| Series: | Journal of Leather Science and Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42825-020-00043-y |
| _version_ | 1818326076159426560 |
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| author | Lei Xiang Wenguo Cui |
| author_facet | Lei Xiang Wenguo Cui |
| author_sort | Lei Xiang |
| collection | DOAJ |
| description | Abstract During the past decades, photo-crosslinked gelatin hydrogel (methacrylated gelatin, GelMA) has gained a lot of attention due to its remarkable application in the biomedical field. It has been widely used in cell transplantation, cell culture and drug delivery, based on its crosslinking to form hydrogels with tunable mechanical properties and excellent bio-compatibility when exposed to light irradiation to mimic the micro-environment of native extracellular matrix (ECM). Because of its unique biofunctionality and mechanical tenability, it has also been widely applied in the repair and regeneration of bone, heart, cornea, epidermal tissue, cartilage, vascular, peripheral nerve, oral mucosa, and skeletal muscle et al. The purpose of this review is to summarize the recent application of GelMA in drug delivery and tissue engineering field. Moreover, this review article will briefly introduce both the development of GelMA and the characterization of GelMA. Finally, we discuss the challenges and future development prospects of GelMA as a tissue engineering material and drug or gene delivery carrier, hoping to contribute to accelerating the development of GelMA in the biomedical field. Graphical abstract |
| first_indexed | 2024-12-13T11:54:37Z |
| format | Article |
| id | doaj.art-3b58ce646648477991b6ffbdff83cd0d |
| institution | Directory Open Access Journal |
| issn | 2524-7859 |
| language | English |
| last_indexed | 2024-12-13T11:54:37Z |
| publishDate | 2021-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Leather Science and Engineering |
| spelling | doaj.art-3b58ce646648477991b6ffbdff83cd0d2022-12-21T23:47:15ZengSpringerOpenJournal of Leather Science and Engineering2524-78592021-02-013112410.1186/s42825-020-00043-yBiomedical application of photo-crosslinked gelatin hydrogelsLei Xiang0Wenguo Cui1Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineShanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineAbstract During the past decades, photo-crosslinked gelatin hydrogel (methacrylated gelatin, GelMA) has gained a lot of attention due to its remarkable application in the biomedical field. It has been widely used in cell transplantation, cell culture and drug delivery, based on its crosslinking to form hydrogels with tunable mechanical properties and excellent bio-compatibility when exposed to light irradiation to mimic the micro-environment of native extracellular matrix (ECM). Because of its unique biofunctionality and mechanical tenability, it has also been widely applied in the repair and regeneration of bone, heart, cornea, epidermal tissue, cartilage, vascular, peripheral nerve, oral mucosa, and skeletal muscle et al. The purpose of this review is to summarize the recent application of GelMA in drug delivery and tissue engineering field. Moreover, this review article will briefly introduce both the development of GelMA and the characterization of GelMA. Finally, we discuss the challenges and future development prospects of GelMA as a tissue engineering material and drug or gene delivery carrier, hoping to contribute to accelerating the development of GelMA in the biomedical field. Graphical abstracthttps://doi.org/10.1186/s42825-020-00043-yGelatinGelatin methacryloylBiomedical applicationHydrogelsPhoto crosslink |
| spellingShingle | Lei Xiang Wenguo Cui Biomedical application of photo-crosslinked gelatin hydrogels Journal of Leather Science and Engineering Gelatin Gelatin methacryloyl Biomedical application Hydrogels Photo crosslink |
| title | Biomedical application of photo-crosslinked gelatin hydrogels |
| title_full | Biomedical application of photo-crosslinked gelatin hydrogels |
| title_fullStr | Biomedical application of photo-crosslinked gelatin hydrogels |
| title_full_unstemmed | Biomedical application of photo-crosslinked gelatin hydrogels |
| title_short | Biomedical application of photo-crosslinked gelatin hydrogels |
| title_sort | biomedical application of photo crosslinked gelatin hydrogels |
| topic | Gelatin Gelatin methacryloyl Biomedical application Hydrogels Photo crosslink |
| url | https://doi.org/10.1186/s42825-020-00043-y |
| work_keys_str_mv | AT leixiang biomedicalapplicationofphotocrosslinkedgelatinhydrogels AT wenguocui biomedicalapplicationofphotocrosslinkedgelatinhydrogels |