An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes
Nanostructured Lipid Carriers (NLC) are nano-sized colloidal drug delivery system that contains a lipid mixture consisting of both solid and liquid lipids in their core. This Lipid-Based Nanosystem is introduced as a biocompatible, non-toxic, and safe nano-drug delivery system as compared to polymer...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2023-07-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | https://apb.tbzmed.ac.ir/PDF/apb-13-446.pdf |
| _version_ | 1797673429211545600 |
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| author | Shadab Khan Ajay Sharma Vikas Jain |
| author_facet | Shadab Khan Ajay Sharma Vikas Jain |
| author_sort | Shadab Khan |
| collection | DOAJ |
| description | Nanostructured Lipid Carriers (NLC) are nano-sized colloidal drug delivery system that contains a lipid mixture consisting of both solid and liquid lipids in their core. This Lipid-Based Nanosystem is introduced as a biocompatible, non-toxic, and safe nano-drug delivery system as compared to polymeric or metallic nanoparticles. Due to its safety, stability, and high drug loading capacity compared to other lipid-based nanocarriers, NLC gained the attention of researchers to formulate safe and effective drug carriers. The ability to increase drug solubility and permeability while encapsulating the drug in a lipidic shell makes them an ideal carrier for drug delivery through difficult-to-achieve routes. Surface modification of NLC and the use of various additives result in drug targeting and increased residence time. With such qualities, NLCs can be used to treat a variety of diseases such as cancer, infections, neurodegenerative diseases, hypertension, diabetes, and pain management. This review focuses on the recent developments being made to deliver the drugs and genes through different routes via these nanocarriers. Here, we also discuss about historical background, structure, types of NLC and commonly employed techniques for manufacturing lipid-based nanocarriers. |
| first_indexed | 2024-03-11T21:44:25Z |
| format | Article |
| id | doaj.art-3b58fefd1a8d4511abf890ff9b346caf |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-03-11T21:44:25Z |
| publishDate | 2023-07-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-3b58fefd1a8d4511abf890ff9b346caf2023-09-26T10:41:42ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082023-07-0113344646010.34172/apb.2023.056apb-34577An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different RoutesShadab Khan0Ajay Sharma1Vikas Jain2Mahakal Institute of Pharmaceutical Studies, Ujjain, India.Mahakal Institute of Pharmaceutical Studies, Ujjain, India.Mahakal Institute of Pharmaceutical Studies, Ujjain, India.Nanostructured Lipid Carriers (NLC) are nano-sized colloidal drug delivery system that contains a lipid mixture consisting of both solid and liquid lipids in their core. This Lipid-Based Nanosystem is introduced as a biocompatible, non-toxic, and safe nano-drug delivery system as compared to polymeric or metallic nanoparticles. Due to its safety, stability, and high drug loading capacity compared to other lipid-based nanocarriers, NLC gained the attention of researchers to formulate safe and effective drug carriers. The ability to increase drug solubility and permeability while encapsulating the drug in a lipidic shell makes them an ideal carrier for drug delivery through difficult-to-achieve routes. Surface modification of NLC and the use of various additives result in drug targeting and increased residence time. With such qualities, NLCs can be used to treat a variety of diseases such as cancer, infections, neurodegenerative diseases, hypertension, diabetes, and pain management. This review focuses on the recent developments being made to deliver the drugs and genes through different routes via these nanocarriers. Here, we also discuss about historical background, structure, types of NLC and commonly employed techniques for manufacturing lipid-based nanocarriers.https://apb.tbzmed.ac.ir/PDF/apb-13-446.pdfdrug delivery systemslipidsnanoparticlesdrug carrierspermeabilityoralophthalmicintransal |
| spellingShingle | Shadab Khan Ajay Sharma Vikas Jain An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes Advanced Pharmaceutical Bulletin drug delivery systems lipids nanoparticles drug carriers permeability oral ophthalmic intransal |
| title | An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes |
| title_full | An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes |
| title_fullStr | An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes |
| title_full_unstemmed | An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes |
| title_short | An Overview of Nanostructured Lipid Carriers and its Application in Drug Delivery through Different Routes |
| title_sort | overview of nanostructured lipid carriers and its application in drug delivery through different routes |
| topic | drug delivery systems lipids nanoparticles drug carriers permeability oral ophthalmic intransal |
| url | https://apb.tbzmed.ac.ir/PDF/apb-13-446.pdf |
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