Palmomental reflex is an important clinical marker of REM sleep behavior disorder in patients with Parkinson’s disease
OBJECTIVES: To find important clinical features in differentiating patients with Parkinson’s disease (PD) with and without rapid eye movement sleep behavior disorder (RBD). METHODS: This study was a prospective, questionnaire-based study performed at the National Institute of Mental health and Neuro...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Annals of Movement Disorders |
| Subjects: | |
| Online Access: | http://www.aomd.in/article.asp?issn=2590-3446;year=2018;volume=1;issue=1;spage=44;epage=48;aulast=Yadav |
| _version_ | 1818152237335052288 |
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| author | Ravi Yadav Rohan Mahale Pramod K Pal |
| author_facet | Ravi Yadav Rohan Mahale Pramod K Pal |
| author_sort | Ravi Yadav |
| collection | DOAJ |
| description | OBJECTIVES: To find important clinical features in differentiating patients with Parkinson’s disease (PD) with and without rapid eye movement sleep behavior disorder (RBD).
METHODS: This study was a prospective, questionnaire-based study performed at the National Institute of Mental health and Neurosciences, Bangalore, after prior institutional ethical approval. Patients with PD were clinically examined and the presence of RBD was diagnosed using the minimal criteria for the diagnosis of RBD (International Classification of Sleep Disorders-1). RBD screening questionnaire based on the minimal criteria was used. The bed-partners were interviewed with Mayo sleep questionnaire. Other scales included Unified Parkinson’s Disease Rating Scale-part III (UPDRS-III), Hoehn and Yahr Stage, Mini-Mental Status Examination (MMSE), Pittsburgh sleep quality index, Parkinson’s Disease Sleep Scale, Epworth Sleep Scale (ESS), Hamilton anxiety rating scale (HAM-A), and Hamilton depression rating scale (HAM-D).
RESULTS: A total of 126 patients with PD without RBD (mean age: 61.1±9.8 years) and 30 with RBD (mean age 54.1±11.1 years) were enrolled. The patients with RBD had higher gait score (P < 0.05), higher HAM-A (P = 0.02), and higher ESS score (P < 0.001) as compared to patients without RBD. Patients with RBD had a mean MMSE score of 26.87±2.31 (range: 23–30), and in patients, without RBD it was 27.98±2.33 (range: 23–30;. P = 0.005). There was no difference in features as olfactory dysfunction, rigidity score, blink rate, tremors, stooped stance, and postural instability in the two groups. However, palmomental reflex was present in 63.3% of patients with RBD and only 34.9% with non-RBD (P = 0.007).
CONCLUSIONS: Patients with PD with RBD have a significant presence of palmomental reflex that can be a useful clinical marker. |
| first_indexed | 2024-12-11T13:51:32Z |
| format | Article |
| id | doaj.art-3b59447d8c8243c3af69375207f62901 |
| institution | Directory Open Access Journal |
| issn | 2590-3446 2590-3454 |
| language | English |
| last_indexed | 2024-12-11T13:51:32Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Movement Disorders |
| spelling | doaj.art-3b59447d8c8243c3af69375207f629012022-12-22T01:04:15ZengWolters Kluwer Medknow PublicationsAnnals of Movement Disorders2590-34462590-34542018-01-0111444810.4103/AOMD.AOMD_7_18Palmomental reflex is an important clinical marker of REM sleep behavior disorder in patients with Parkinson’s diseaseRavi YadavRohan MahalePramod K PalOBJECTIVES: To find important clinical features in differentiating patients with Parkinson’s disease (PD) with and without rapid eye movement sleep behavior disorder (RBD). METHODS: This study was a prospective, questionnaire-based study performed at the National Institute of Mental health and Neurosciences, Bangalore, after prior institutional ethical approval. Patients with PD were clinically examined and the presence of RBD was diagnosed using the minimal criteria for the diagnosis of RBD (International Classification of Sleep Disorders-1). RBD screening questionnaire based on the minimal criteria was used. The bed-partners were interviewed with Mayo sleep questionnaire. Other scales included Unified Parkinson’s Disease Rating Scale-part III (UPDRS-III), Hoehn and Yahr Stage, Mini-Mental Status Examination (MMSE), Pittsburgh sleep quality index, Parkinson’s Disease Sleep Scale, Epworth Sleep Scale (ESS), Hamilton anxiety rating scale (HAM-A), and Hamilton depression rating scale (HAM-D). RESULTS: A total of 126 patients with PD without RBD (mean age: 61.1±9.8 years) and 30 with RBD (mean age 54.1±11.1 years) were enrolled. The patients with RBD had higher gait score (P < 0.05), higher HAM-A (P = 0.02), and higher ESS score (P < 0.001) as compared to patients without RBD. Patients with RBD had a mean MMSE score of 26.87±2.31 (range: 23–30), and in patients, without RBD it was 27.98±2.33 (range: 23–30;. P = 0.005). There was no difference in features as olfactory dysfunction, rigidity score, blink rate, tremors, stooped stance, and postural instability in the two groups. However, palmomental reflex was present in 63.3% of patients with RBD and only 34.9% with non-RBD (P = 0.007). CONCLUSIONS: Patients with PD with RBD have a significant presence of palmomental reflex that can be a useful clinical marker.http://www.aomd.in/article.asp?issn=2590-3446;year=2018;volume=1;issue=1;spage=44;epage=48;aulast=Yadavpalmomental reflexparkinson’s diseaseprimitive reflexrem sleep behavior disorders |
| spellingShingle | Ravi Yadav Rohan Mahale Pramod K Pal Palmomental reflex is an important clinical marker of REM sleep behavior disorder in patients with Parkinson’s disease Annals of Movement Disorders palmomental reflex parkinson’s disease primitive reflex rem sleep behavior disorders |
| title | Palmomental reflex is an important clinical marker of REM sleep behavior disorder in patients with Parkinson’s disease |
| title_full | Palmomental reflex is an important clinical marker of REM sleep behavior disorder in patients with Parkinson’s disease |
| title_fullStr | Palmomental reflex is an important clinical marker of REM sleep behavior disorder in patients with Parkinson’s disease |
| title_full_unstemmed | Palmomental reflex is an important clinical marker of REM sleep behavior disorder in patients with Parkinson’s disease |
| title_short | Palmomental reflex is an important clinical marker of REM sleep behavior disorder in patients with Parkinson’s disease |
| title_sort | palmomental reflex is an important clinical marker of rem sleep behavior disorder in patients with parkinson s disease |
| topic | palmomental reflex parkinson’s disease primitive reflex rem sleep behavior disorders |
| url | http://www.aomd.in/article.asp?issn=2590-3446;year=2018;volume=1;issue=1;spage=44;epage=48;aulast=Yadav |
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