Colonization, Infection and Risk Factors for Death in an Infectious Disease ICU in Romania
Knowing the bacterial strains in the intensive care unit (ICU) is important for reducing the rate of bacterial transmission and the risk of healthcare-associated infections (HAIs), allowing for targeted interventions to reduce the risk of death by HAIs. We performed a retrospective case-control stud...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Media Med Publicis
2023-09-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2023/09/Colonization-Infection-and-Risk-Factors-for-Death-in-an-Infectious-Disease-ICU-in-Romania.pdf |
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| author | Nicoleta-Dorina VLAD Andreea CAPILNA Anca DUMITRESCU Aurora CRACIUN Sergiu CHIRILA Tony HANGAN Elena DUMEA Septimiu VOIDAZAN Sorin RUGINA Claudia-Simona CAMBREA Irina-Magdalena DUMITRU |
| author_facet | Nicoleta-Dorina VLAD Andreea CAPILNA Anca DUMITRESCU Aurora CRACIUN Sergiu CHIRILA Tony HANGAN Elena DUMEA Septimiu VOIDAZAN Sorin RUGINA Claudia-Simona CAMBREA Irina-Magdalena DUMITRU |
| author_sort | Nicoleta-Dorina VLAD |
| collection | DOAJ |
| description | Knowing the bacterial strains in the intensive care unit (ICU) is important for reducing the rate of bacterial transmission and the risk of healthcare-associated infections (HAIs), allowing for targeted interventions to reduce the risk of death by HAIs. We performed a retrospective case-control study in a single center that included 320 bacteriologically screened patients from the ICU of the Infectious Diseases Hospital in Constanta between September 2017 and March 2020. Sixty-five secondary bacterial infections were identified as the cause of hospital admission and 60 bacterial colonizations. There were 20 cases and 300 controls for the mortality rate and risk factors for death. Multivariate analysis identified that hospitalization of patients for HIV infection (OR 11.82, 95% CI: 1.69-83.62, P ≤0.05) and Clostridioides difficile infection (OR 7.38, 95% CI: 1.39 -39.22, P ≤ 0.05) were independent risk factors associated with death. We observed that the number of colonizations or secondary infections in the ICU was similar, and the mortality rate in the ICU was influenced by HIV infection or Clostridioides difficile infection. |
| first_indexed | 2024-03-11T21:42:32Z |
| format | Article |
| id | doaj.art-3b5a74eb6a5c4c0ab7d615732c0043ca |
| institution | Directory Open Access Journal |
| issn | 1223-0472 2360-2473 |
| language | English |
| last_indexed | 2024-03-11T21:42:32Z |
| publishDate | 2023-09-01 |
| publisher | Media Med Publicis |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj.art-3b5a74eb6a5c4c0ab7d615732c0043ca2023-09-26T12:34:36ZengMedia Med PublicisModern Medicine1223-04722360-24732023-09-01303181190https://doi.org/10.31689/rmm.2023.30.3.181Colonization, Infection and Risk Factors for Death in an Infectious Disease ICU in RomaniaNicoleta-Dorina VLAD0https://orcid.org/0000-0003-1230-6819Andreea CAPILNA1Anca DUMITRESCU2Aurora CRACIUN3Sergiu CHIRILA4https://orcid.org/0000-0003-3275-2330Tony HANGAN5Elena DUMEA6https://orcid.org/0000-0002-4679-899XSeptimiu VOIDAZAN7https://orcid.org/0000-0002-6467-6275Sorin RUGINA8https://orcid.org/0000-0002-1570-9632Claudia-Simona CAMBREA9https://orcid.org/0000-0003-4898-8938Irina-Magdalena DUMITRU10https://orcid.org/0000-0001-9184-8223Doctoral School of Medicine, Ovidius University of Constanta, Aleea Universitatii nr.1, 900470 Constanta, RomaniaMilitary Hospital Regina Maria Brasov, 9 Pieţii Str, 500007 Brasov, RomaniaClinical Infectious Diseases Hospital, 100 Ferdinand Str, 900709 Constanta, RomaniaFaculty of Medicine, Ovidius University of Constanţa, Aleea Universitatii, nr.1, 900470 Constanta, RomaniaFaculty of Medicine, Ovidius University of Constanţa, Aleea Universitatii, nr.1, 900470 Constanta, RomaniaFaculty of Medicine, Ovidius University of Constanţa, Aleea Universitatii, nr.1, 900470 Constanta, RomaniaFaculty of Medicine, Ovidius University of Constanţa, Aleea Universitatii, nr.1, 900470 Constanta, RomaniaGeorge Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gheorghe Marinescu Str, 540142, Târgu Mureș, RomaniaRomanian Academy of Medical Sciences, Spl Independentei, nr. 54, 50085, Bucharest, RomaniaFaculty of Medicine, Ovidius University of Constanţa, Aleea Universitatii, nr.1, 900470 Constanta, RomaniaFaculty of Medicine, Ovidius University of Constanţa, Aleea Universitatii, nr.1, 900470 Constanta, RomaniaKnowing the bacterial strains in the intensive care unit (ICU) is important for reducing the rate of bacterial transmission and the risk of healthcare-associated infections (HAIs), allowing for targeted interventions to reduce the risk of death by HAIs. We performed a retrospective case-control study in a single center that included 320 bacteriologically screened patients from the ICU of the Infectious Diseases Hospital in Constanta between September 2017 and March 2020. Sixty-five secondary bacterial infections were identified as the cause of hospital admission and 60 bacterial colonizations. There were 20 cases and 300 controls for the mortality rate and risk factors for death. Multivariate analysis identified that hospitalization of patients for HIV infection (OR 11.82, 95% CI: 1.69-83.62, P ≤0.05) and Clostridioides difficile infection (OR 7.38, 95% CI: 1.39 -39.22, P ≤ 0.05) were independent risk factors associated with death. We observed that the number of colonizations or secondary infections in the ICU was similar, and the mortality rate in the ICU was influenced by HIV infection or Clostridioides difficile infection. https://medicinamoderna.ro/wp-content/uploads/2023/09/Colonization-Infection-and-Risk-Factors-for-Death-in-an-Infectious-Disease-ICU-in-Romania.pdfmortalityrisk factorscolonizationinfection |
| spellingShingle | Nicoleta-Dorina VLAD Andreea CAPILNA Anca DUMITRESCU Aurora CRACIUN Sergiu CHIRILA Tony HANGAN Elena DUMEA Septimiu VOIDAZAN Sorin RUGINA Claudia-Simona CAMBREA Irina-Magdalena DUMITRU Colonization, Infection and Risk Factors for Death in an Infectious Disease ICU in Romania Modern Medicine mortality risk factors colonization infection |
| title | Colonization, Infection and Risk Factors for Death in an Infectious Disease ICU in Romania |
| title_full | Colonization, Infection and Risk Factors for Death in an Infectious Disease ICU in Romania |
| title_fullStr | Colonization, Infection and Risk Factors for Death in an Infectious Disease ICU in Romania |
| title_full_unstemmed | Colonization, Infection and Risk Factors for Death in an Infectious Disease ICU in Romania |
| title_short | Colonization, Infection and Risk Factors for Death in an Infectious Disease ICU in Romania |
| title_sort | colonization infection and risk factors for death in an infectious disease icu in romania |
| topic | mortality risk factors colonization infection |
| url | https://medicinamoderna.ro/wp-content/uploads/2023/09/Colonization-Infection-and-Risk-Factors-for-Death-in-an-Infectious-Disease-ICU-in-Romania.pdf |
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