Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools
<h4>Background</h4> The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) showed no significant improvement for decades, however, the impact of advances in diagnostic tools is rarely mentioned. This study investigated the clin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846538/?tool=EBI |
| _version_ | 1818974975520931840 |
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| author | Shih-Wei Wang Leong-Perng Chan Ling-Feng Wang Che-Wei Wu Sheng-Hsuan Lin Tzu-Yen Huang Ka-Wo Lee |
| author_facet | Shih-Wei Wang Leong-Perng Chan Ling-Feng Wang Che-Wei Wu Sheng-Hsuan Lin Tzu-Yen Huang Ka-Wo Lee |
| author_sort | Shih-Wei Wang |
| collection | DOAJ |
| description | <h4>Background</h4> The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) showed no significant improvement for decades, however, the impact of advances in diagnostic tools is rarely mentioned. This study investigated the clinical characteristic of HNSCC with SPM over a 27-year period especially from the perspective of diagnostic tools. <h4>Methods</h4> This study evaluated 157 HNSCC patients with SPM. The patients were divided into two groups according to the time of SPM diagnosis (Group A:1992–2003; Group B: 2004–2014). Age, gender, stage of first primary malignancy (FPM), SPM interval, overall survival, and disease-free survival were compared between groups. <h4>Results</h4> Group B had significantly more SPM developed rate (p = 0.002), more SPM patients with advanced stage of FPM (p = 0.001), synchronous SPM (p = 0.006), and shorter SPM interval (p<0.001) compared to Group A. The survival rate in Group B was not significantly better than Group A. <h4>Conclusion</h4> Among patients diagnosed with HNSCC recently, more SPMs are diagnosed in a shorter time interval and in a more advanced stage. The overall advances in diagnostic tools cannot significantly improve SPM survival, however, it enables more patients to receive corresponding treatment. |
| first_indexed | 2024-12-20T15:48:36Z |
| format | Article |
| id | doaj.art-3b5bbb558a5640fca83d13ea268e0b2c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T15:48:36Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-3b5bbb558a5640fca83d13ea268e0b2c2022-12-21T19:34:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01172Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic toolsShih-Wei WangLeong-Perng ChanLing-Feng WangChe-Wei WuSheng-Hsuan LinTzu-Yen HuangKa-Wo Lee<h4>Background</h4> The survival rate of head and neck squamous cell carcinoma (HNSCC) patients with secondary primary malignancy (SPM) showed no significant improvement for decades, however, the impact of advances in diagnostic tools is rarely mentioned. This study investigated the clinical characteristic of HNSCC with SPM over a 27-year period especially from the perspective of diagnostic tools. <h4>Methods</h4> This study evaluated 157 HNSCC patients with SPM. The patients were divided into two groups according to the time of SPM diagnosis (Group A:1992–2003; Group B: 2004–2014). Age, gender, stage of first primary malignancy (FPM), SPM interval, overall survival, and disease-free survival were compared between groups. <h4>Results</h4> Group B had significantly more SPM developed rate (p = 0.002), more SPM patients with advanced stage of FPM (p = 0.001), synchronous SPM (p = 0.006), and shorter SPM interval (p<0.001) compared to Group A. The survival rate in Group B was not significantly better than Group A. <h4>Conclusion</h4> Among patients diagnosed with HNSCC recently, more SPMs are diagnosed in a shorter time interval and in a more advanced stage. The overall advances in diagnostic tools cannot significantly improve SPM survival, however, it enables more patients to receive corresponding treatment.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846538/?tool=EBI |
| spellingShingle | Shih-Wei Wang Leong-Perng Chan Ling-Feng Wang Che-Wei Wu Sheng-Hsuan Lin Tzu-Yen Huang Ka-Wo Lee Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools PLoS ONE |
| title | Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools |
| title_full | Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools |
| title_fullStr | Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools |
| title_full_unstemmed | Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools |
| title_short | Secondary primary malignancy in patients with head and neck squamous cell carcinoma: 27-year experience from the perspective of diagnostic tools |
| title_sort | secondary primary malignancy in patients with head and neck squamous cell carcinoma 27 year experience from the perspective of diagnostic tools |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846538/?tool=EBI |
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