Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion Injury
Ischemia-reperfusion injury (IRI) is a process in which damage is induced in hypoxic tissue when oxygen supply is resumed after ischemia. During IRI, restoration of reduced nitric oxide (NO) levels may alleviate reperfusion injury in ischemic organs. The protective mechanism of NO is due to anti-inf...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/1/57 |
| _version_ | 1827667008211124224 |
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| author | Hyang-Mi Lee Ji Woong Choi Min Sik Choi |
| author_facet | Hyang-Mi Lee Ji Woong Choi Min Sik Choi |
| author_sort | Hyang-Mi Lee |
| collection | DOAJ |
| description | Ischemia-reperfusion injury (IRI) is a process in which damage is induced in hypoxic tissue when oxygen supply is resumed after ischemia. During IRI, restoration of reduced nitric oxide (NO) levels may alleviate reperfusion injury in ischemic organs. The protective mechanism of NO is due to anti-inflammatory effects, antioxidant effects, and the regulation of cell signaling pathways. On the other hand, it is generally known that S-nitrosylation (SNO) mediates the detrimental or protective effect of NO depending on the action of the nitrosylated target protein, and this is also applied in the IRI process. In this review, the effect of each change of NO and SNO during the IRI process was investigated. |
| first_indexed | 2024-03-10T03:00:37Z |
| format | Article |
| id | doaj.art-3b5bca4027354a12b4f197af61effbee |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T03:00:37Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-3b5bca4027354a12b4f197af61effbee2023-11-23T12:46:37ZengMDPI AGAntioxidants2076-39212021-12-011115710.3390/antiox11010057Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion InjuryHyang-Mi Lee0Ji Woong Choi1Min Sik Choi2College of Pharmacy, Dongduk Women’s University, Seoul 02748, KoreaCollege of Pharmacy, Gachon University, Incheon 21936, KoreaLaboratory of Pharmacology, College of Pharmacy, Dongduk Women’s University, Seoul 02748, KoreaIschemia-reperfusion injury (IRI) is a process in which damage is induced in hypoxic tissue when oxygen supply is resumed after ischemia. During IRI, restoration of reduced nitric oxide (NO) levels may alleviate reperfusion injury in ischemic organs. The protective mechanism of NO is due to anti-inflammatory effects, antioxidant effects, and the regulation of cell signaling pathways. On the other hand, it is generally known that S-nitrosylation (SNO) mediates the detrimental or protective effect of NO depending on the action of the nitrosylated target protein, and this is also applied in the IRI process. In this review, the effect of each change of NO and SNO during the IRI process was investigated.https://www.mdpi.com/2076-3921/11/1/57ischemia-reperfusion injurynitric oxideprotein S-nitrosylation |
| spellingShingle | Hyang-Mi Lee Ji Woong Choi Min Sik Choi Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion Injury Antioxidants ischemia-reperfusion injury nitric oxide protein S-nitrosylation |
| title | Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion Injury |
| title_full | Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion Injury |
| title_fullStr | Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion Injury |
| title_full_unstemmed | Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion Injury |
| title_short | Role of Nitric Oxide and Protein S-Nitrosylation in Ischemia-Reperfusion Injury |
| title_sort | role of nitric oxide and protein s nitrosylation in ischemia reperfusion injury |
| topic | ischemia-reperfusion injury nitric oxide protein S-nitrosylation |
| url | https://www.mdpi.com/2076-3921/11/1/57 |
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