Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in <i>Aspergillus nidulans</i>. <i>J. Fungi</i> 2021, <i>7</i>, 560
Contrary to the opinion recently offered by Dimou et al., our previously published biochemical, subcellular and genetic data supported our contention that AN11127 corresponds to the <i>A. nidulans</i> gene encoding Sec12, which is the guanine nucleotide exchange factor (GEF) specific for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/7/12/1037 |
| _version_ | 1797503238701842432 |
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| author | Ignacio Bravo-Plaza Miguel Hernández-González Miguel Á. Peñalva |
| author_facet | Ignacio Bravo-Plaza Miguel Hernández-González Miguel Á. Peñalva |
| author_sort | Ignacio Bravo-Plaza |
| collection | DOAJ |
| description | Contrary to the opinion recently offered by Dimou et al., our previously published biochemical, subcellular and genetic data supported our contention that AN11127 corresponds to the <i>A. nidulans</i> gene encoding Sec12, which is the guanine nucleotide exchange factor (GEF) specific for SAR1. We add here additional bioinformatics evidence that fully disprove the otherwise negative evidence reported by Dimou et al., highlighting the dangers associated with the lax interpretation of genomic data. On the positive side, we establish guidelines for the identification of this key secretory gene in other species of Ascomycota and Basidiomycota, including species of medical and applied interest. |
| first_indexed | 2024-03-10T03:47:42Z |
| format | Article |
| id | doaj.art-3b5c18f18832462dafed766b487525af |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T03:47:42Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-3b5c18f18832462dafed766b487525af2023-11-23T09:04:56ZengMDPI AGJournal of Fungi2309-608X2021-12-01712103710.3390/jof7121037Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in <i>Aspergillus nidulans</i>. <i>J. Fungi</i> 2021, <i>7</i>, 560Ignacio Bravo-Plaza0Miguel Hernández-González1Miguel Á. Peñalva2Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28049 Madrid, SpainThe Francis Crick Institute, 1 Midland Road, London NW1 1AT, UKCentro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28049 Madrid, SpainContrary to the opinion recently offered by Dimou et al., our previously published biochemical, subcellular and genetic data supported our contention that AN11127 corresponds to the <i>A. nidulans</i> gene encoding Sec12, which is the guanine nucleotide exchange factor (GEF) specific for SAR1. We add here additional bioinformatics evidence that fully disprove the otherwise negative evidence reported by Dimou et al., highlighting the dangers associated with the lax interpretation of genomic data. On the positive side, we establish guidelines for the identification of this key secretory gene in other species of Ascomycota and Basidiomycota, including species of medical and applied interest.https://www.mdpi.com/2309-608X/7/12/1037gene callingSAR1ARF GEF<i>Ascomycota</i><i>Aspergilli</i> |
| spellingShingle | Ignacio Bravo-Plaza Miguel Hernández-González Miguel Á. Peñalva Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in <i>Aspergillus nidulans</i>. <i>J. Fungi</i> 2021, <i>7</i>, 560 Journal of Fungi gene calling SAR1 ARF GEF <i>Ascomycota</i> <i>Aspergilli</i> |
| title | Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in <i>Aspergillus nidulans</i>. <i>J. Fungi</i> 2021, <i>7</i>, 560 |
| title_full | Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in <i>Aspergillus nidulans</i>. <i>J. Fungi</i> 2021, <i>7</i>, 560 |
| title_fullStr | Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in <i>Aspergillus nidulans</i>. <i>J. Fungi</i> 2021, <i>7</i>, 560 |
| title_full_unstemmed | Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in <i>Aspergillus nidulans</i>. <i>J. Fungi</i> 2021, <i>7</i>, 560 |
| title_short | Comment on Dimou et al. Profile of Membrane Cargo Trafficking Proteins and Transporters Expressed under N Source Derepressing Conditions in <i>Aspergillus nidulans</i>. <i>J. Fungi</i> 2021, <i>7</i>, 560 |
| title_sort | comment on dimou et al profile of membrane cargo trafficking proteins and transporters expressed under n source derepressing conditions in i aspergillus nidulans i i j fungi i 2021 i 7 i 560 |
| topic | gene calling SAR1 ARF GEF <i>Ascomycota</i> <i>Aspergilli</i> |
| url | https://www.mdpi.com/2309-608X/7/12/1037 |
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