Macrophages in the Aging Liver and Age-Related Liver Disease
The number of individuals aged 65 or older is projected to increase globally from 524 million in 2010 to nearly 1. 5 billion in 2050. Aged individuals are particularly at risk for developing chronic illness, while being less able to regenerate healthy tissue and tolerate whole organ transplantation...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02795/full |
| _version_ | 1818139049489072128 |
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| author | Elizabeth C. Stahl Martin J. Haschak Branimir Popovic Bryan N. Brown |
| author_facet | Elizabeth C. Stahl Martin J. Haschak Branimir Popovic Bryan N. Brown |
| author_sort | Elizabeth C. Stahl |
| collection | DOAJ |
| description | The number of individuals aged 65 or older is projected to increase globally from 524 million in 2010 to nearly 1. 5 billion in 2050. Aged individuals are particularly at risk for developing chronic illness, while being less able to regenerate healthy tissue and tolerate whole organ transplantation procedures. In the liver, these age-related diseases include non-alcoholic fatty liver disease, alcoholic liver disease, hepatitis, fibrosis, and cirrhosis. Hepatic macrophages, a population comprised of both Kupffer cells and infiltrating monocyte derived macrophages, are implicated in several chronic liver diseases and also play important roles in the homeostatic functions of the liver. The effects of aging on hepatic macrophage population dynamics, polarization, and function are not well understood. Studies performed on macrophages derived from other aged sources, such as the bone marrow, peritoneal cavity, lungs, and brain, demonstrate general reductions in autophagy and phagocytosis, dysfunction in cytokine signaling, and altered morphology and distribution, likely mediated by epigenetic changes and mitochondrial defects, that may be applicable to hepatic macrophages. This review highlights recent findings in macrophage developmental biology and function, particularly in the liver, and discusses the role of macrophages in various age-related liver diseases. A better understanding of the biology of aging that influences hepatic macrophages and thus the progression of chronic liver disease will be crucial in order to develop new interventions and treatments for liver disease in aging populations. |
| first_indexed | 2024-12-11T10:21:55Z |
| format | Article |
| id | doaj.art-3b5c71c18a3645e3a2cf0ffe73ce515f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T10:21:55Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-3b5c71c18a3645e3a2cf0ffe73ce515f2022-12-22T01:11:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-11-01910.3389/fimmu.2018.02795422500Macrophages in the Aging Liver and Age-Related Liver DiseaseElizabeth C. StahlMartin J. HaschakBranimir PopovicBryan N. BrownThe number of individuals aged 65 or older is projected to increase globally from 524 million in 2010 to nearly 1. 5 billion in 2050. Aged individuals are particularly at risk for developing chronic illness, while being less able to regenerate healthy tissue and tolerate whole organ transplantation procedures. In the liver, these age-related diseases include non-alcoholic fatty liver disease, alcoholic liver disease, hepatitis, fibrosis, and cirrhosis. Hepatic macrophages, a population comprised of both Kupffer cells and infiltrating monocyte derived macrophages, are implicated in several chronic liver diseases and also play important roles in the homeostatic functions of the liver. The effects of aging on hepatic macrophage population dynamics, polarization, and function are not well understood. Studies performed on macrophages derived from other aged sources, such as the bone marrow, peritoneal cavity, lungs, and brain, demonstrate general reductions in autophagy and phagocytosis, dysfunction in cytokine signaling, and altered morphology and distribution, likely mediated by epigenetic changes and mitochondrial defects, that may be applicable to hepatic macrophages. This review highlights recent findings in macrophage developmental biology and function, particularly in the liver, and discusses the role of macrophages in various age-related liver diseases. A better understanding of the biology of aging that influences hepatic macrophages and thus the progression of chronic liver disease will be crucial in order to develop new interventions and treatments for liver disease in aging populations.https://www.frontiersin.org/article/10.3389/fimmu.2018.02795/fullKupffer cellmonocyte-derived macrophagechronic liver diseaseinflammationfibrosissenescence |
| spellingShingle | Elizabeth C. Stahl Martin J. Haschak Branimir Popovic Bryan N. Brown Macrophages in the Aging Liver and Age-Related Liver Disease Frontiers in Immunology Kupffer cell monocyte-derived macrophage chronic liver disease inflammation fibrosis senescence |
| title | Macrophages in the Aging Liver and Age-Related Liver Disease |
| title_full | Macrophages in the Aging Liver and Age-Related Liver Disease |
| title_fullStr | Macrophages in the Aging Liver and Age-Related Liver Disease |
| title_full_unstemmed | Macrophages in the Aging Liver and Age-Related Liver Disease |
| title_short | Macrophages in the Aging Liver and Age-Related Liver Disease |
| title_sort | macrophages in the aging liver and age related liver disease |
| topic | Kupffer cell monocyte-derived macrophage chronic liver disease inflammation fibrosis senescence |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02795/full |
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