Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beads
Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of residual malignant tumor of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with drug-eluting beads (DEBs). Subjects and Methods: Pre-contrast T1, T2, dyna...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-04-01
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| Series: | Indian Journal of Radiology and Imaging |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_383_18 |
| _version_ | 1819087166473502720 |
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| author | Ahmed E Hassan Radwa E Mostafa Ayman Nada Mohamed S Elazab Ahmed Sayed Awad Ikram M Hamed |
| author_facet | Ahmed E Hassan Radwa E Mostafa Ayman Nada Mohamed S Elazab Ahmed Sayed Awad Ikram M Hamed |
| author_sort | Ahmed E Hassan |
| collection | DOAJ |
| description | Purpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of residual malignant tumor of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with drug-eluting beads (DEBs). Subjects and Methods: Pre-contrast T1, T2, dynamic contrast–enhanced, and respiratory-triggered DW-MRI (b factor 0, 400, and 800 s/mm2) were obtained in 60 patients with HCC who underwent tran-sarterial hepatic chemoembolization with DEBs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for the DW imaging images. Apparent diffusion coefficients (ADCs) were calculated searching for the optimal cut-off value using the receiver operating characteristic (ROC) curve. Results: DW-MRI had a sensitivity of 77.1%, a specificity of 60.7%, a PPV of 71.05%, and a NPV of 68%. The difference between the malignant and benign groups’ ADC variables was statistically significant (P < 0.003). The ROC curve showed that the area under the curve is C = 0.718 with SE = 0.069 and 95% confidence interval from 0.548 to 0.852. Conclusion: In our study, we demonstrated that diffusion MRI has limited diagnostic value in the assessment of viable tumor tissue after TACE with DEBs in cases of HCC. |
| first_indexed | 2024-12-21T21:31:49Z |
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| id | doaj.art-3b5e40265a664af7a06a1d0a085129ec |
| institution | Directory Open Access Journal |
| issn | 0971-3026 1998-3808 |
| language | English |
| last_indexed | 2024-12-21T21:31:49Z |
| publishDate | 2019-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Radiology and Imaging |
| spelling | doaj.art-3b5e40265a664af7a06a1d0a085129ec2022-12-21T18:49:36ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Radiology and Imaging0971-30261998-38082019-04-01290219520010.4103/ijri.IJRI_383_18Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beadsAhmed E Hassan0Radwa E Mostafa1Ayman Nada2Mohamed S Elazab3Ahmed Sayed Awad4Ikram M Hamed5Department of Diagnostic and Interventional Radiology, National Cancer Institute, Cairo University, Cairo, EgyptDepartment of Diagnostic and Interventional Radiology, National Cancer Institute, Cairo University, Cairo, EgyptDepartment of Radiology, University of Missouri, USADepartment of Diagnostic and Interventional Radiology, National Cancer Institute, Cairo University, Cairo, EgyptDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Cairo University, Cairo, EgyptDepartment of Diagnostic and Interventional Radiology, National Cancer Institute, Cairo University, Cairo, EgyptPurpose: To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of residual malignant tumor of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with drug-eluting beads (DEBs). Subjects and Methods: Pre-contrast T1, T2, dynamic contrast–enhanced, and respiratory-triggered DW-MRI (b factor 0, 400, and 800 s/mm2) were obtained in 60 patients with HCC who underwent tran-sarterial hepatic chemoembolization with DEBs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for the DW imaging images. Apparent diffusion coefficients (ADCs) were calculated searching for the optimal cut-off value using the receiver operating characteristic (ROC) curve. Results: DW-MRI had a sensitivity of 77.1%, a specificity of 60.7%, a PPV of 71.05%, and a NPV of 68%. The difference between the malignant and benign groups’ ADC variables was statistically significant (P < 0.003). The ROC curve showed that the area under the curve is C = 0.718 with SE = 0.069 and 95% confidence interval from 0.548 to 0.852. Conclusion: In our study, we demonstrated that diffusion MRI has limited diagnostic value in the assessment of viable tumor tissue after TACE with DEBs in cases of HCC.http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_383_18drug-eluting beadsdiffusion-weighted magnetic resonance imaginghepatocellular carcinoma-transcatheter arterialchemoembolization; hepatic; malignant |
| spellingShingle | Ahmed E Hassan Radwa E Mostafa Ayman Nada Mohamed S Elazab Ahmed Sayed Awad Ikram M Hamed Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beads Indian Journal of Radiology and Imaging drug-eluting beads diffusion-weighted magnetic resonance imaging hepatocellular carcinoma-transcatheter arterial chemoembolization; hepatic; malignant |
| title | Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beads |
| title_full | Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beads |
| title_fullStr | Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beads |
| title_full_unstemmed | Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beads |
| title_short | Diagnostic accuracy of intermediate b-value diffusion-weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug-eluting beads |
| title_sort | diagnostic accuracy of intermediate b value diffusion weighted imaging for detection of residual hepatocellular carcinoma following transarterial chemoembolization with drug eluting beads |
| topic | drug-eluting beads diffusion-weighted magnetic resonance imaging hepatocellular carcinoma-transcatheter arterial chemoembolization; hepatic; malignant |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/ijri.IJRI_383_18 |
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