Registry of intra-articular hyaluronic acid in the treatment of knee osteoarthritis in Argentina
Background: Intra-articular treatment of knee osteoarthrosis (OA) with hyaluronic acid (IA-HA) is frequently used in Argentina, with different dosing forms and injection regimens. Our main objective was to provide real world data on the use and effectiveness of IA-HA Methods: In this observational r...
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| Format: | Article |
| Language: | English |
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Asociación Argentina de Ortopedia y Traumatología
2019-05-01
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| Series: | Revista de la Asociación Argentina de Ortopedia y Traumatología |
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| Online Access: | https://ojs.aaot.org.ar/ojsr/index.php/AAOTMAG/article/view/846 |
| _version_ | 1827617056096256000 |
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| author | Mario Berenstein Leonardo Tacus Pablo Kobrinsky Daniel Vaineras |
| author_facet | Mario Berenstein Leonardo Tacus Pablo Kobrinsky Daniel Vaineras |
| author_sort | Mario Berenstein |
| collection | DOAJ |
| description | Background: Intra-articular treatment of knee osteoarthrosis (OA) with hyaluronic acid (IA-HA) is frequently used in Argentina, with different dosing forms and injection regimens. Our main objective was to provide real world data on the use and effectiveness of IA-HA
Methods: In this observational retrospective cohort study we studied 1227 patients with knee osteoarthrosis treated with IA-HA 20mg/2ml weekly (76%-20mg group) and 40mg/2ml (24%-40mg group) according to usual practice intervals. Follow up was at 6 months and efficacy assessed by 5 point Likert scale and 50% or more response rate.
Results: Median number of applications was 5 (20mg) and 3 (40mg). Both groups had a significant improvement in the Likert scale from baseline to 6 month. Median score improved from 4 (mean 3.77 ±0.69) at baseline to median of 2 (mean 1.99 ±0.76) at 6 months (20mg group, p <0.001) and from median of 4 (mean 3.65 ±0.65) to median 2 (mean 1.86 ±0.72) in the 40mg group, p <0.001. Proportion of patients with 50% or more 6 month response were 61% and 66% respectively. In the multivariate analysis, 50% response rate was associated with higher baseline score, younger age and shorter duration of disease. Only 1 patient in the 20mg group (0.1%) experienced a serious treatment related adverse event (septic arthritis) following injection.
Conclusion: Our study in common clinical practice supports the effectiveness of IA-HA in step management of knee OA with clinical benefit observed at 6 month follow up. |
| first_indexed | 2024-03-09T09:36:34Z |
| format | Article |
| id | doaj.art-3b5e758739f740fb92bfbdc47b483b19 |
| institution | Directory Open Access Journal |
| issn | 1515-1786 1852-7434 |
| language | English |
| last_indexed | 2024-03-09T09:36:34Z |
| publishDate | 2019-05-01 |
| publisher | Asociación Argentina de Ortopedia y Traumatología |
| record_format | Article |
| series | Revista de la Asociación Argentina de Ortopedia y Traumatología |
| spelling | doaj.art-3b5e758739f740fb92bfbdc47b483b192023-12-02T01:19:27ZengAsociación Argentina de Ortopedia y TraumatologíaRevista de la Asociación Argentina de Ortopedia y Traumatología1515-17861852-74342019-05-0184212212810.15417/issn.1852-7434.2019.84.2.846423Registry of intra-articular hyaluronic acid in the treatment of knee osteoarthritis in ArgentinaMario Berenstein0Leonardo Tacus1Pablo Kobrinsky2Daniel Vaineras3Equipo Traumatológico Olleros, Olleros 2411, Piso 10°2, Ciudad Autónoma de Buenos Aires, Argentina Tel: +5411 4778-6329; Cel 154-4064751 Mail personal: marioberenstein@gmail.comInvestigaciones Artroscópicas (IAR) Av Las Heras 1947, Piso 8 Ciudad Autónoma de Buenos Aires, ArgentinaInvestigaciones Artroscópicas (IAR) Av Las Heras 1947, Piso 8 Ciudad Autónoma de Buenos Aires, ArgentinaEquipo Traumatológico Olleros, Olleros 2411, Piso 10°2, Ciudad Autónoma de Buenos Aires, ArgentinaBackground: Intra-articular treatment of knee osteoarthrosis (OA) with hyaluronic acid (IA-HA) is frequently used in Argentina, with different dosing forms and injection regimens. Our main objective was to provide real world data on the use and effectiveness of IA-HA Methods: In this observational retrospective cohort study we studied 1227 patients with knee osteoarthrosis treated with IA-HA 20mg/2ml weekly (76%-20mg group) and 40mg/2ml (24%-40mg group) according to usual practice intervals. Follow up was at 6 months and efficacy assessed by 5 point Likert scale and 50% or more response rate. Results: Median number of applications was 5 (20mg) and 3 (40mg). Both groups had a significant improvement in the Likert scale from baseline to 6 month. Median score improved from 4 (mean 3.77 ±0.69) at baseline to median of 2 (mean 1.99 ±0.76) at 6 months (20mg group, p <0.001) and from median of 4 (mean 3.65 ±0.65) to median 2 (mean 1.86 ±0.72) in the 40mg group, p <0.001. Proportion of patients with 50% or more 6 month response were 61% and 66% respectively. In the multivariate analysis, 50% response rate was associated with higher baseline score, younger age and shorter duration of disease. Only 1 patient in the 20mg group (0.1%) experienced a serious treatment related adverse event (septic arthritis) following injection. Conclusion: Our study in common clinical practice supports the effectiveness of IA-HA in step management of knee OA with clinical benefit observed at 6 month follow up.https://ojs.aaot.org.ar/ojsr/index.php/AAOTMAG/article/view/846Intra-articularhyaluronic acidkneearthrosisosteoarthritis |
| spellingShingle | Mario Berenstein Leonardo Tacus Pablo Kobrinsky Daniel Vaineras Registry of intra-articular hyaluronic acid in the treatment of knee osteoarthritis in Argentina Revista de la Asociación Argentina de Ortopedia y Traumatología Intra-articular hyaluronic acid knee arthrosis osteoarthritis |
| title | Registry of intra-articular hyaluronic acid in the treatment of knee osteoarthritis in Argentina |
| title_full | Registry of intra-articular hyaluronic acid in the treatment of knee osteoarthritis in Argentina |
| title_fullStr | Registry of intra-articular hyaluronic acid in the treatment of knee osteoarthritis in Argentina |
| title_full_unstemmed | Registry of intra-articular hyaluronic acid in the treatment of knee osteoarthritis in Argentina |
| title_short | Registry of intra-articular hyaluronic acid in the treatment of knee osteoarthritis in Argentina |
| title_sort | registry of intra articular hyaluronic acid in the treatment of knee osteoarthritis in argentina |
| topic | Intra-articular hyaluronic acid knee arthrosis osteoarthritis |
| url | https://ojs.aaot.org.ar/ojsr/index.php/AAOTMAG/article/view/846 |
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