The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.
Bibliographic Details
| Main Authors: |
Johanna Grinat,
Julian Heuberger,
Ramon Oliveira Vidal,
Neha Goveas,
Frauke Kosel,
Antoni Berenguer-Llergo,
Andrea Kranz,
Annika Wulf-Goldenberg,
Diana Behrens,
Bálint Melcher,
Sascha Sauer,
Michael Vieth,
Eduard Batlle,
A. Francis Stewart,
Walter Birchmeier |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-20222-z
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