The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness
Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20222-z |
| _version_ | 1818749710728429568 |
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| author | Johanna Grinat Julian Heuberger Ramon Oliveira Vidal Neha Goveas Frauke Kosel Antoni Berenguer-Llergo Andrea Kranz Annika Wulf-Goldenberg Diana Behrens Bálint Melcher Sascha Sauer Michael Vieth Eduard Batlle A. Francis Stewart Walter Birchmeier |
| author_facet | Johanna Grinat Julian Heuberger Ramon Oliveira Vidal Neha Goveas Frauke Kosel Antoni Berenguer-Llergo Andrea Kranz Annika Wulf-Goldenberg Diana Behrens Bálint Melcher Sascha Sauer Michael Vieth Eduard Batlle A. Francis Stewart Walter Birchmeier |
| author_sort | Johanna Grinat |
| collection | DOAJ |
| description | Intestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models. |
| first_indexed | 2024-12-18T04:08:07Z |
| format | Article |
| id | doaj.art-3b5f2ff3d1124d7c81f483c2f20a5a38 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:08:07Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3b5f2ff3d1124d7c81f483c2f20a5a382022-12-21T21:21:33ZengNature PortfolioNature Communications2041-17232020-12-0111111510.1038/s41467-020-20222-zThe epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemnessJohanna Grinat0Julian Heuberger1Ramon Oliveira Vidal2Neha Goveas3Frauke Kosel4Antoni Berenguer-Llergo5Andrea Kranz6Annika Wulf-Goldenberg7Diana Behrens8Bálint Melcher9Sascha Sauer10Michael Vieth11Eduard Batlle12A. Francis Stewart13Walter Birchmeier14Cancer Research Program, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz SocietyCancer Research Program, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz SocietyLaboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH)Biotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität DresdenCancer Research Program, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz SocietyBiostatistics and Bioinformatics Unit, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyBiotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität DresdenExperimental Pharmacology & Oncology (EPO)Experimental Pharmacology & Oncology (EPO)Institute for Pathology, Klinikum BayreuthLaboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH)Institute for Pathology, Klinikum BayreuthInstitute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyBiotechnology Center, Center for Molecular and Cellular Bioengineering, Technische Universität DresdenCancer Research Program, Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz SocietyIntestinal cancer stem cells (CSC) are associated with colon cancer. Here, the authors show that Wnt/beta-catenin signalling in CSC requires the epigenetic regulator Mll1 to promote stemness and tumourigenesis in murine and human colon cancer models.https://doi.org/10.1038/s41467-020-20222-z |
| spellingShingle | Johanna Grinat Julian Heuberger Ramon Oliveira Vidal Neha Goveas Frauke Kosel Antoni Berenguer-Llergo Andrea Kranz Annika Wulf-Goldenberg Diana Behrens Bálint Melcher Sascha Sauer Michael Vieth Eduard Batlle A. Francis Stewart Walter Birchmeier The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness Nature Communications |
| title | The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness |
| title_full | The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness |
| title_fullStr | The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness |
| title_full_unstemmed | The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness |
| title_short | The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness |
| title_sort | epigenetic regulator mll1 is required for wnt driven intestinal tumorigenesis and cancer stemness |
| url | https://doi.org/10.1038/s41467-020-20222-z |
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