A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish

A comparative analysis of gene and protein expression in chronic and acute models of photoreceptor degeneration in adult zebrafish

Background: Adult zebrafish are capable of photoreceptor (PR) regeneration following acute phototoxic lesion (AL). We developed a chronic low light (CLL) exposure model that more accurately reflects chronic PR degeneration observed in many human retinal diseases.Methods: Here, we characterize the mo...

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Bibliographic Details
Main Authors: Ashley C. Kramer, Justin Carthage, Yasmeen Berry, Katherine Gurdziel, Tiffany A. Cook, Ryan Thummel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
photoreceptor degeneration
chronic light
microglia
Müller glia
stem cell
rod precursor
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1233269/full

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