Carcinosarcoma of lung
<p>Primary carcinosarcoma of the lung is exceedingly rare. It is described as malignancy composed of a mixture of carcinoma and sarcoma elements. The sarcomatous element is usually spindle cell but may contain cartilage, bone or skeletal muscle. We report a case of pulmonary carcinosarcoma in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Association of Clinical Pathologists of Nepal
2013-03-01
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| Series: | Journal of Pathology of Nepal |
| Subjects: | |
| Online Access: | http://www.nepjol.info/index.php/JPN/article/view/7873 |
| Summary: | <p>Primary carcinosarcoma of the lung is exceedingly rare. It is described as malignancy composed of a mixture of carcinoma and sarcoma elements. The sarcomatous element is usually spindle cell but may contain cartilage, bone or skeletal muscle. We report a case of pulmonary carcinosarcoma in a 66 years male who presented with cough, chest pain on exertion, anorexia and weight loss. Brush cytology revealed poorly differentiated non-small cell carcinoma. Histopathological examination showed proliferation of malignant spindle cells containing bone and malignant cartilage admixed with areas of keratinized squamous cells with few foci of ill-defined glandular structure. On immunohistochemistry, carcinomatous component of tumor showed positivity for cytokeratin AE1/AE3 and spindle cell component were positive for vimentin. These findings led to diagnosis of carcinosarcoma.</p> <p>Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 419-421</p> <p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v3i5.7873">http://dx.doi.org/10.3126/jpn.v3i5.7873</a></p> |
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| ISSN: | 2091-0797 2091-0908 |