Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters
Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/5/1040 |
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| author | Blessing D. Mkhonazi Malibongwe Shandu Ronewa Tshinavhe Sandile B. Simelane Paseka T. Moshapo |
| author_facet | Blessing D. Mkhonazi Malibongwe Shandu Ronewa Tshinavhe Sandile B. Simelane Paseka T. Moshapo |
| author_sort | Blessing D. Mkhonazi |
| collection | DOAJ |
| description | Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%. |
| first_indexed | 2024-04-13T16:01:44Z |
| format | Article |
| id | doaj.art-3b60eca0c63540d0b3fed629668dfd26 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T16:01:44Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-3b60eca0c63540d0b3fed629668dfd262022-12-22T02:40:31ZengMDPI AGMolecules1420-30492020-02-01255104010.3390/molecules25051040molecules25051040Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of EstersBlessing D. Mkhonazi0Malibongwe Shandu1Ronewa Tshinavhe2Sandile B. Simelane3Paseka T. Moshapo4Research Centre in Synthesis and Catalysis, Department of Chemical Science, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South AfricaResearch Centre in Synthesis and Catalysis, Department of Chemical Science, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South AfricaResearch Centre in Synthesis and Catalysis, Department of Chemical Science, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South AfricaDepartment of Chemistry, University of Eswatini, Private Bag 4, Kwaluseni M201, EswatiniResearch Centre in Synthesis and Catalysis, Department of Chemical Science, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South AfricaAmide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%.https://www.mdpi.com/1420-3049/25/5/1040amidationiron(iii) chlorideamidesesterssolvent-free |
| spellingShingle | Blessing D. Mkhonazi Malibongwe Shandu Ronewa Tshinavhe Sandile B. Simelane Paseka T. Moshapo Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters Molecules amidation iron(iii) chloride amides esters solvent-free |
| title | Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters |
| title_full | Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters |
| title_fullStr | Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters |
| title_full_unstemmed | Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters |
| title_short | Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters |
| title_sort | solvent free iron iii chloride catalyzed direct amidation of esters |
| topic | amidation iron(iii) chloride amides esters solvent-free |
| url | https://www.mdpi.com/1420-3049/25/5/1040 |
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