The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy
Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer sensitivity to glutaminase-targeted therapy.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11321 |
| _version_ | 1819035683214327808 |
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| author | Michael J. Lukey Kai Su Greene Jon W. Erickson Kristin F. Wilson Richard A. Cerione |
| author_facet | Michael J. Lukey Kai Su Greene Jon W. Erickson Kristin F. Wilson Richard A. Cerione |
| author_sort | Michael J. Lukey |
| collection | DOAJ |
| description | Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer sensitivity to glutaminase-targeted therapy. |
| first_indexed | 2024-12-21T07:53:31Z |
| format | Article |
| id | doaj.art-3b613416e0fb4b2589fd4ff157971900 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T07:53:31Z |
| publishDate | 2016-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-3b613416e0fb4b2589fd4ff1579719002022-12-21T19:11:01ZengNature PortfolioNature Communications2041-17232016-04-017111410.1038/ncomms11321The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapyMichael J. Lukey0Kai Su Greene1Jon W. Erickson2Kristin F. Wilson3Richard A. Cerione4Department of Molecular Medicine, Cornell UniversityDepartment of Molecular Medicine, Cornell UniversityDepartment of Chemistry and Chemical Biology, Cornell UniversityDepartment of Molecular Medicine, Cornell UniversityDepartment of Molecular Medicine, Cornell UniversityCancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to confer sensitivity to glutaminase-targeted therapy.https://doi.org/10.1038/ncomms11321 |
| spellingShingle | Michael J. Lukey Kai Su Greene Jon W. Erickson Kristin F. Wilson Richard A. Cerione The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy Nature Communications |
| title | The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy |
| title_full | The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy |
| title_fullStr | The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy |
| title_full_unstemmed | The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy |
| title_short | The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy |
| title_sort | oncogenic transcription factor c jun regulates glutaminase expression and sensitizes cells to glutaminase targeted therapy |
| url | https://doi.org/10.1038/ncomms11321 |
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