Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells

Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells

The alveolar epithelium represents a major site of tissue destruction during lung injury. It consists of alveolar epithelial type I (ATI) and type II (ATII) cells. ATII cells are capable of self-renewal and exert progenitor function for ATI cells upon alveolar epithelial injury. Cell differentiation...

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Bibliographic Details
Main Authors: Kathrin Mutze, Sarah Vierkotten, Jadranka Milosevic, Oliver Eickelberg, Melanie Königshoff
Format: Article
Language:English
Published: The Company of Biologists 2015-08-01
Series:Disease Models & Mechanisms
Subjects:
Alveolar epithelial cells
Differentiation
Lung injury and repair
Beta-catenin
Wnt pathway
Fibrosis
Online Access:http://dmm.biologists.org/content/8/8/877

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