Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage
Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated. Mesenchymal stem cells have become ideal candidates for ma...
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| Format: | Article |
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MDPI AG
2020-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/1/42 |
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| author | Xiaoyu Pu Siyang Ma Yan Gao Tiankai Xu Pengyu Chang Lihua Dong |
| author_facet | Xiaoyu Pu Siyang Ma Yan Gao Tiankai Xu Pengyu Chang Lihua Dong |
| author_sort | Xiaoyu Pu |
| collection | DOAJ |
| description | Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated. Mesenchymal stem cells have become ideal candidates for managing radiation-induced damage. Moreover, accumulating evidence suggests that exosomes derived from mesenchymal stem cells have a similar effect on repairing tissue damage mainly because these exosomes carry various bioactive substances, such as miRNAs, proteins and lipids, which can affect immunomodulation, angiogenesis, and cell survival and proliferation. Although the mechanisms by which mesenchymal stem cell-derived exosomes repair radiation damage have not been fully elucidated, we intend to translate their biological features into a radiation damage model and aim to provide new insight into the management of radiation damage. |
| first_indexed | 2024-03-10T13:40:29Z |
| format | Article |
| id | doaj.art-3b6456acfd814f74a3d9f90f4a9c8106 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:40:29Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-3b6456acfd814f74a3d9f90f4a9c81062023-11-21T03:04:43ZengMDPI AGCells2073-44092020-12-011014210.3390/cells10010042Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation DamageXiaoyu Pu0Siyang Ma1Yan Gao2Tiankai Xu3Pengyu Chang4Lihua Dong5Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, Department of Radiation Oncology & Therapy, The First Bethune Hospital of Jilin University, Changchun 130021, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, Department of Radiation Oncology & Therapy, The First Bethune Hospital of Jilin University, Changchun 130021, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, Department of Radiation Oncology & Therapy, The First Bethune Hospital of Jilin University, Changchun 130021, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, Department of Radiation Oncology & Therapy, The First Bethune Hospital of Jilin University, Changchun 130021, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, Department of Radiation Oncology & Therapy, The First Bethune Hospital of Jilin University, Changchun 130021, ChinaJilin Provincial Key Laboratory of Radiation Oncology & Therapy, Department of Radiation Oncology & Therapy, The First Bethune Hospital of Jilin University, Changchun 130021, ChinaRadiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated. Mesenchymal stem cells have become ideal candidates for managing radiation-induced damage. Moreover, accumulating evidence suggests that exosomes derived from mesenchymal stem cells have a similar effect on repairing tissue damage mainly because these exosomes carry various bioactive substances, such as miRNAs, proteins and lipids, which can affect immunomodulation, angiogenesis, and cell survival and proliferation. Although the mechanisms by which mesenchymal stem cell-derived exosomes repair radiation damage have not been fully elucidated, we intend to translate their biological features into a radiation damage model and aim to provide new insight into the management of radiation damage.https://www.mdpi.com/2073-4409/10/1/42mesenchymal stem cellexosomeradiation damage |
| spellingShingle | Xiaoyu Pu Siyang Ma Yan Gao Tiankai Xu Pengyu Chang Lihua Dong Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage Cells mesenchymal stem cell exosome radiation damage |
| title | Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage |
| title_full | Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage |
| title_fullStr | Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage |
| title_short | Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage |
| title_sort | mesenchymal stem cell derived exosomes biological function and their therapeutic potential in radiation damage |
| topic | mesenchymal stem cell exosome radiation damage |
| url | https://www.mdpi.com/2073-4409/10/1/42 |
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