Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?
Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple...
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MDPI AG
2022-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/9/874 |
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| author | Cristina Morán-Serradilla Eduardo Angulo-Elizari Andreina Henriquez-Figuereo Carmen Sanmartín Arun K. Sharma Daniel Plano |
| author_facet | Cristina Morán-Serradilla Eduardo Angulo-Elizari Andreina Henriquez-Figuereo Carmen Sanmartín Arun K. Sharma Daniel Plano |
| author_sort | Cristina Morán-Serradilla |
| collection | DOAJ |
| description | Selenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe<sup>−</sup>/H<sub>2</sub>Se) and methylselenol (CH<sub>3</sub>SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies. |
| first_indexed | 2024-03-09T23:10:34Z |
| format | Article |
| id | doaj.art-3b64c6c90ddb447eb024e4c130ada093 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T23:10:34Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-3b64c6c90ddb447eb024e4c130ada0932023-11-23T17:45:13ZengMDPI AGMetabolites2218-19892022-09-0112987410.3390/metabo12090874Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?Cristina Morán-Serradilla0Eduardo Angulo-Elizari1Andreina Henriquez-Figuereo2Carmen Sanmartín3Arun K. Sharma4Daniel Plano5Department of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, E-31008 Pamplona, SpainDepartment of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, E-31008 Pamplona, SpainDepartment of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, E-31008 Pamplona, SpainDepartment of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, E-31008 Pamplona, SpainDepartment of Pharmacology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USADepartment of Pharmaceutical Technology and Chemistry, University of Navarra, Irunlarrea 1, E-31008 Pamplona, SpainSelenium (Se) is an essential element for human health as it is involved in different physiological functions. Moreover, a great number of Se compounds can be considered potential agents in the prevention and treatment of some diseases. It is widely recognized that Se activity is related to multiple factors, such as its chemical form, dose, and its metabolism. The understanding of its complex biochemistry is necessary as it has been demonstrated that the metabolites of the Se molecules used to be the ones that exert the biological activity. Therefore, the aim of this review is to summarize the recent information about its most remarkable metabolites of acknowledged biological effects: hydrogen selenide (HSe<sup>−</sup>/H<sub>2</sub>Se) and methylselenol (CH<sub>3</sub>SeH). In addition, special attention is paid to the main seleno-containing precursors of these derivatives and their role in different pathologies.https://www.mdpi.com/2218-1989/12/9/874seleniumseleno-metabolitesH<sub>2</sub>Se-precursorsCH<sub>3</sub>SeH-precursorsbioactive agentscancer |
| spellingShingle | Cristina Morán-Serradilla Eduardo Angulo-Elizari Andreina Henriquez-Figuereo Carmen Sanmartín Arun K. Sharma Daniel Plano Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses? Metabolites selenium seleno-metabolites H<sub>2</sub>Se-precursors CH<sub>3</sub>SeH-precursors bioactive agents cancer |
| title | Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses? |
| title_full | Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses? |
| title_fullStr | Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses? |
| title_full_unstemmed | Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses? |
| title_short | Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses? |
| title_sort | seleno metabolites and their precursors a new dawn for several illnesses |
| topic | selenium seleno-metabolites H<sub>2</sub>Se-precursors CH<sub>3</sub>SeH-precursors bioactive agents cancer |
| url | https://www.mdpi.com/2218-1989/12/9/874 |
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